羟苯磺酸钙胶囊联合复方血栓通胶囊治疗玻璃体积血的疗效观察  

Observation on Efficacy of Calcium Dobesilate Capsule Combined with Compound Xueshuantong Capsule in Treatment of Vitreous Hemorrhage

作　　者：罗慧娟 吴远松 

机构地区：[1]宜都市第一人民医院五官科,湖北宜都443300

出　　处：《中国医院用药评价与分析》2018年第2期182-184,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨羟苯磺酸钙胶囊联合复方血栓通胶囊治疗玻璃体积血的疗效。方法:选取2015年3月—2016年4月宜都市第一人民医院收治的玻璃体积血患者98例,以随机数字表法分为观察组和对照组,每组49例。对照组患者给予羟苯磺酸钙胶囊,观察组患者在对照组基础上加用复方血栓通胶囊。对比观察两组患者的临床疗效、出血斑面积、黄斑厚度、视野灰度值、血管瘤体积、血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)水平及不良反应发生情况。结果:观察组患者的总有效率为91.8%(45/49),明显高于对照组的77.6%(38/49),差异有统计学意义(P<0.05);治疗后,两组患者出血斑面积、黄斑厚度、视野灰度值及血管瘤体积均较治疗前明显改善,且观察组患者明显优于对照组,差异均有统计学意义(P<0.05);治疗后,两组患者血清VEGF、IGF-1水平均较治疗前明显降低,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05);观察组患者不良反应发生率为8.0%(4/49),明显低于对照组的30.6%(15/49),差异有统计学意义(P<0.05)。结论:羟苯磺酸钙胶囊联合复方血栓通胶囊治疗玻璃体积血的疗效显著,可有效改善患者临床症状,提高视力,降低血清VEGF和IGF-1水平,且不良反应少。OBJECTIVE： To probe into the efficacy of Calcium dobesilate capsule combined with compound Xueshuantong capsule in treatment of vitreous hemorrhage. METHODS： 98 patients with vitreous hemorrhage admitted into Yidu the First People＇s Hospital from Mar. 2015 to Apr. 2016 were selected and divided into observation group and control group via random number table,with 49 cases in each. The control group was treated with Calcium dobesilate capsule,while the observation group was given Calcium dobesilate capsule combined with compound Xueshuantong capsule. Clinical efficacy,areas of hemorrhage spot,thicknesses of macular lutea,gray values of vision,volumes of hemangioma,level of serum vascular endothelial growth factor（ VEGF）,level of serum insulin-like growth factor 1（ IGF-1） and incidences of adverse drug reactions of two groups were observed and compared.RESULTS： The total effective rate of observation group was 91. 8%（ 45/49）,which was significantly higher than that of the control group（ 77. 6%,38/49）,with statistically significant difference（ P〈0. 05）; after treatment,the areas of hemorrhage spot,thicknesses of macular lutea,gray values of vision and volumes of hemangioma of both groups had been significantly improved,and those of the observation group were significantly better than the control group,with statistically significant differences（ P〈0. 05）; after treatment,levels of serum VEGF and IGF-1 of both groups had been significantly decreased,and those of the observation group were significantly lower than the control group,with statistically significant differences（ P〈0. 05）; the incidence of adverse drug reactions of observation group was 8. 0%（ 4/49）,which was significantly lower than that of the control group（ 30. 6%,15/49）,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The efficacy of Calcium dobesilate capsule combined with compound Xueshuantong capsule in treatment of vitreous hemorrhage is remarkable,which can significantly imp

关 键 词：羟苯磺酸钙 复方血栓通胶囊 玻璃体积血 糖尿病性视网膜病变 疗效 

分 类 号：R988.1[医药卫生—药品]