Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes  

作　　者：Mengyu Guo Guoqiang Zhou Zhu Liu Jing Liu Jinglong Tang Yating Xiao Wenshi Xu Ying Liu Chunying Chen 

机构地区：[1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology,Beijing 100190, China [2]Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding 050011, China [3]University of Chinese Academy Sciences, Beijing 100049, China

出　　处：《Science Bulletin》2018年第2期92-100,共9页科学通报（英文版）

基　　金：supported by the Project Electro Med (11115313) from the Danish Council for Strategic Research;the National Science Fund for Excellent Young Scholars (31622026);the National Natural Science Foundation of China (U1532122, 21320102003, 21471044);the National Key Research and Development Plan (2016YFA0201600, 2016YFA0203204);the National Science Fund for Distinguished Young Scholars (11425520);Youth Innovation Promotion Association of the Chinese Academy of Sciences (2014031)

摘　　要：Doxorubicin （DOX） is widely used in cancer therapy. However, its application is sometimes limited by its adverse cardiotoxicity and delivery pathways. In our study, we prepared a topical implantable delivery device for controlled drug release and site-specific treatment. The core region consisted of poly （lactic co-glycolic acid） and poly-caprolactone, whereas the shell region was composed of cross-linked gelatin. DOX was enclosed in the core region of a core-shell nanofiber obtained by electrospinning. This implantable delivery device was implanted on the top of the melanoma in a mouse model, which had shown a DOX-controlled release profile with sustained and sufficient local concentration against melanoma growth in mice with negligible side effects. Compared with the traditional intravenous administration, the implantable device allows precisely localized treatment and therefore can reduce the dose, decrease the injection frequency, and ensure antitumor efficacy associated with lower side effects to normal tissues. Using a coaxial electrospinning process, it is promising to deliver different hydrophohic or hydrophilic drugs for direct tumor site-specific therapy without large systemic doses and minimized systemic toxicity.Doxorubicin(DOX) is widely used in cancer therapy. However, its application is sometimes limited by its adverse cardiotoxicity and delivery pathways. In our study, we prepared a topical implantable delivery device for controlled drug release and site-specific treatment. The core region consisted of poly(lactic co-glycolic acid) and poly-caprolactone, whereas the shell region was composed of cross-linked gelatin.DOX was enclosed in the core region of a core-shell nanofiber obtained by electrospinning. This implantable delivery device was implanted on the top of the melanoma in a mouse model, which had shown a DOX-controlled release profile with sustained and sufficient local concentration against melanoma growth in mice with negligible side effects. Compared with the traditional intravenous administration,the implantable device allows precisely localized treatment and therefore can reduce the dose, decrease the injection frequency, and ensure antitumor efficacy associated with lower side effects to normal tissues. Using a coaxial electrospinning process, it is promising to deliver different hydrophobic or hydrophilic drugs for direct tumor site-specific therapy without large systemic doses and minimized systemic toxicity.

关 键 词：Core-shell nanofiberMelanomaElectrospinningControlled drug release 

分 类 号：R943[医药卫生—药剂学] R96[医药卫生—药学]