“肺肠合治法”升降相因治疗肠道菌群失调合并过敏性哮喘的免疫机制探讨与思考  

Study on Immunologic Mechanism of Lung-Instestine Simultaneous Treatment Through Interdependence of Descending and Ascending to Treat Atopic Asthma and Enteric Dysbacteriosis

作　　者：刘兴隆[1] 赵静[1] 高永翔[1] 杨宇[1] 刘伟伟[1] 李雪萍[1] 付雯[1] 孙小钧[1] 李雪萍 吴斌[3] 

机构地区：[1]成都中医药大学 [2]成都中医药大学附属医院/四川省中医医院 [3]四川省医学科学院/四川省人民医院

出　　处：《辽宁中医杂志》2018年第1期17-20,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金(81303085);四川省科技厅应用基础项目(2013JY0067)

摘　　要：＂卫生假说＂认为生命早期内环境中微生物的多少与免疫耐受形成和变应性疾病的发生相关。研究发现,过敏性哮喘的发生、发展与早期肠道菌群的紊乱关系密切。肠道菌群失调合并过敏性哮喘属于中医＂肺肠合病＂,根据中医＂肺与大肠相表里＂的理论,＂肺肠合治法＂能够防治菌群失调合并过敏性哮喘。该研究通过饲喂抗生素加白念珠菌定植复制肠道菌群失调,并在此基础上运用卵清蛋白注射致敏与雾化诱发哮喘,考察了肺肠合治方（加味升降散）对模型的作用,并从TLR2、4/My D88信号转导角度初步探讨其免疫机制。According to the＂hygiene hypothesis＂,counts of microbes in the internal environment of our early lives are related to immune tolerance and morbidity of atopic diseases. Studies showed that occurrence and development of atopic asthma is closely associated with disorder of intestinal microflora in early phase. Syndrome differentiation of atopic asthma combined with enteric dysbacteriosis in traditional Chinese medicine involves lung-intestine simultaneous disease,so lung-instestine simultaneous treatment（therapy of treating lungs and intestines simultaneously） can be given according to the theory of lung and large instestine being the interior-exterior related. This study made rat model of intestinal microflora disorder and atopic asthma with feeding Antibiotics plus white fungus colonization and ovalbumin injection respectively. The authors investigated the effects of Feichang Hezhi Formula（modified Shengjiang Powder） and explained the mechanism of action through TLR2 and 4/My D88 signal transduction pathway.

关 键 词：肺肠合治 肠道菌群失调 过敏性哮喘 免疫机制 

分 类 号：R256.12[医药卫生—中医内科学]