隔药灸对子宫内膜异位症大鼠模型治疗作用及机制研究  

Study on the Therapeutic Effect and Mechanism of Herbs-partition Moxibusition on Endometriosis Rat Model

作　　者：张澎[1] 苗芙蕊[2] 

机构地区：[1]广西中医药大学,广西南宁530001 [2]广西中医药大学附属瑞康医院,广西南宁530001

出　　处：《辽宁中医药大学学报》2018年第2期143-146,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广西自然科学基金项目(2015jj BA40025);广西中医药大学硕士研究生科研创新项目(YJS201620)

摘　　要：目的：研究隔药灸治疗子宫内膜异位症大鼠模型的疗效及机制。方法：构建子宫内膜异位症大鼠模型并随机分为治疗组、孕三烯酮组、模型组和假手术组。经治疗后,采集大鼠病灶标本,观察隔药灸对大鼠异位子宫内膜体积的抑制作用,计算抑制率;RT-PCR法检测各组大鼠异位子宫内膜的KDR和PTGS2 m RNA表达。结果：经隔药灸治疗后大鼠模型的异位子宫内膜体积较模型组明显缩小;治疗组大鼠模型的异位子宫内膜PTGS2和KDRm RNA表达均明显低于模型组。结论：隔药灸能明显抑制大鼠模型异位子宫内膜的发展,并且这种治疗作用可能与抑制KDR和PTGS2表达,从而调控异位子宫内膜血管生成有关。Objective：To study the mechanism and effect of herbs-partition moxibusition on rat model of endometriosis.Methods：To establish a rat model of endometriosis and randomly divided into three groups：treatment group,progesterone group,model group and sham operation group.After treatment,the focus specimen of rats were collected to observe the inhibitory effect of moxibustion on endometrium volume of rat model of endometriosis,and the inhibition rate was calculated.KDR and PTGS2 mRNA expression were detected by RT-PCR method on rat model of endometriosis in each groups.Results：Compared with the model group,the volume of ectopic endometrium in each group was significantly reduced after treatment with herbs-partition moxibustion and the expression of PTGS2 and KDR m RNA in ectopic endometrium of treatment group was significantly lower than that of model group.Conclusion：Herbs-partition moxibusition cansignificantly inhibit the growth of endometriosis in rat model,and the therapeutic effect may be related to the regulation of ectopic endometrial angiogenesis by inhibiting the expression of KDR and PTGS2.

关 键 词：子宫内膜异位症 KDR PTGS2 

分 类 号：R245[医药卫生—针灸推拿学] R-332[医药卫生—中医临床基础]