甲基丙烯酸酐改性胶原蛋白的研究  

Study on methylacrylic anhydride modified collagen

作　　者：徐娜 王学川 任龙芳 马向东 石叶叶 XU Na;WANG Xuechuan;REN Longfang;MA Xiangdong;SHI Yeye(College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi＇an 710021, China;National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science ＆ Technology , Xi＇an 710021, China)

机构地区：[1]陕西科技大学轻工科学与工程学院,陕西西安710021 [2]陕西科技大学轻化工程国家级实验教学示范中心,陕西西安710021

出　　处：《中国皮革》2018年第3期9-15,29,共8页China Leather

基　　金：国家自然科学(项目编号:21076120);国家科技部863项目(项目编号:2011AA06A108)

摘　　要：用甲基丙烯酸酐改性胶原蛋白，采用单因素和正交试验研究所得的胶原蛋白乙烯基化改性条件为：温度50℃，反应时间2h，甲基丙烯酸酐的用量为1．5mL。通过核磁（^1H-NMR）和红外光谱（FT-IR）对乙烯基化改性前后的胶原蛋白进行表征，证明胶原蛋白被成功改性并在其分子链上引入C—C双键。并对3种不同相对分子质量的胶原蛋白G1、G2和G3进行乙烯基化改性，发现小分子质量的胶原蛋白改性得到的乙烯基胶原蛋白的取代度较大。Methacrylic anhydride modified collagen （CMA） was prepared by the reaction of collagen with metha- crylic anhydride. Through single- factor and orthogonal experiments, the optimal experimental conditions are obtained, the temperature is 50~C, reaction time is 2h, the dosage of methacrylic anhydride is 1.5mL. The character- ization of 1 hydrogen-nuclear magnetic resonance （1H-NMR） and Fourier transform infrared spectroscopy （FT-IR） show that the vinyl is modified on the collagen successfully. The collagen G1, G2 and G3 with three different relative molecular mass were modified with methacrylic anhydride. The result indicates that the substitution degree （DS） of vinyl modified collagen with small molecular mass collagen is bigger.

关 键 词：废弃胶原蛋白 甲基丙烯酸酐 乙烯基化改性 酰化反应 胶原蛋白分子修饰 

分 类 号：TS51[轻工技术与工程—皮革化学与工程]