不同降压药物治疗高血压的临床疗效  

Clinical efficacy of different antihypertensive drugs in treatment of patients with essential hypertension

作　　者：李园春[1] 杨冬[2] 张秀梅[1] 

机构地区：[1]唐山市丰南区医院心血管内科,河北063300 [2]唐山市丰南区医院超声科,河北063300

出　　处：《江苏医药》2018年第2期179-182,共4页Jiangsu Medical Journal

摘　　要：目的探讨不同降压药物治疗高血压的临床疗效。方法将120例高血压患者随机均分为缬沙坦联合氨氯地平治疗组(A组)和缬沙坦联合氢氯噻嗪治疗组(B组)。治疗8周后,比较两组治疗效果。结果与治疗前相比,两组治疗后24-h SBP、日间SBP、夜间SBP、24-h DBP、日间DBP、夜间DBP、24-h收缩压变异系数、24-h舒张压变异系数以及血浆内皮素、血清C反应蛋白、TNF-α、IL-6水平均降低,血浆一氧化氮水平升高(P<0.05);A组各指标改善较B组更加明显(P<0.05)。结论缬沙坦联合氨氯地平治疗高血压患者的临床效果优于缬沙坦联合氢氯噻嗪,能显著减小血压变异性,减轻内皮功能损伤,降低血清炎症因子水平。Objective To investigate the clinical efficacy of different antihypertensive drugs in the treatment of patients with essential hypertension（EH）. Methods A total of 120 patients with EH was treated with valsartan plus amlodipine （group A, 60 cases） or with valsartan plus hydrochlorothiazide（group B, 60 cases）. Clinical efficacy was compared between two groups after eight weeks. Results Compared with before, 24-h SBP, dSBP, nSBP, 24-h DBP, dDBP, nDBP, 24-h SCV, 24-h DCV and levels of plasma endothelin, serum C-reactive protein, TNF-α, IL-6 were all significantly decreased and plasma level of nitric oxide was increased after treatment in both groups（P〈0.05）, which were all improved more obviously in group A than those in group B （P〈0.05）. Conclusion Clinical efficacy of valsartan combined with amlodipine in the treatment of patients with EH is better than that of valsartan combined with hydrochlorothiazide in reducing blood pressure variability, alleviating endothelial dysfunction and downregulating serum levels of inflammatory factors.

关 键 词：缬沙坦 氨氯地平 氢氯噻嗪 高血压 

分 类 号：R544[医药卫生—心血管疾病]