磷脂酰肌醇信号在GLUT4囊泡转运中的调控作用  

The Regulatory Role of Phosphatidylinositol Signaling in GLUT4 Vesicle Trafficking

作　　者：肖玫 赵旭琴 许迎科[2] 李汉兵 

机构地区：[1]浙江工业大学药学院药理研究所,杭州310014 [2]浙江大学生物医学工程与仪器科学学院生物医学工程系浙江省心脑血管检测技术与药效评价重点实验室,杭州310027

出　　处：《中国细胞生物学学报》2018年第1期139-145,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31571480;31611130037);浙江省自然科学基金(批准号:LY18H070004;LR18H180001)资助的课题~~

摘　　要：葡萄糖转运蛋白4(glucose transporter 4,GLUT4)参与胰岛素敏感的脂肪细胞和肌肉细胞中的葡萄糖转运,对机体葡萄糖代谢至关重要。磷脂酰肌醇作为各种蛋白质的定位信号,参与调控细胞生长和新陈代谢,在胰岛素信号转导过程中起着关键作用。在过去的几十年里,关于磷脂酰肌醇信号调控GLUT4囊泡转运方面已有了很大的进展。该文总结了磷脂酰肌醇在GLUT4囊泡转运中的调控作用。Glucose transporter 4（GLUT4） is essential for the uptake of glucose into insulin-sensitive adipocytes and muscle cells and for its intracellular metabolism. Phosphatidylinositol, which works as localization signal of various proteins, plays an important role in regulation of cell growth, metabolism and insulin signaling transduction. Over the last few decades, much progress has been made on studying of the role of phosphatidylinositol signaling and GLUT4 translocation. This review summarizes the latest research on the regulatory role of phosphatidylinositol in intracellular GLUT4 vesicle trafficking.

关 键 词：葡萄糖转运蛋白 囊泡转运 磷脂酰肌醇 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学]