病原菌耐药性与血清PCT水平关系的分析  

Analysis of relationship between antibiotic-resistance of clinical pathogenic bacteria and serum procalcitonin level

作　　者：罗迪[1] 高歌[1] 赵润苓 刘丽杰[1] 

机构地区：[1]大连市第二人民医院检验科,辽宁大连116000 [2]大连市第二人民医院内分泌科,辽宁大连116000

出　　处：《中国微生态学杂志》2018年第2期203-205,共3页Chinese Journal of Microecology

摘　　要：目的了解病原菌不同的耐药性对患者血清降钙素原(PCT)水平的影响。方法运用酶联免疫荧光法检测30例普通耐药铜绿假单胞菌感染患者,30例泛耐药铜绿假单胞菌感染患者,30例普通耐药金黄色葡萄球菌感染患者,30例泛耐药金黄色葡萄球菌感染患者,以及40例健康体检者(对照组)血清中PCT的水平。结果铜绿假单胞菌感染组患者PCT水平明显高于金黄色葡萄球菌感染组(P<0.01),且两组均明显高于对照组(P均<0.05),普通耐药菌组患者PCT水平明显低于泛耐药菌组(P均<0.01),且两组均明显高于对照组(P均<0.05)。结论革兰阴性菌感染时,PCT水平显著高于革兰阳性菌感染,且病原菌耐药性越高,PCT水平升高越显著。Objective To understand the effect of different drug resistance on serum procalcitonin levels in patients.Methods An immunofluorescence method was used to detect the level of serum procalcitonin in 30 cases of general drug resistance Pseudomonas aeruginosainfection,30 cases of pan-drug resistance Pseudomonas aeruginosainfection,30 cases of general resistance to Staphylococcus aureus infection,30 cases of pan-drug resistance to Staphylococcus aureus infection,and 40 cases health checkers（control group）.Results The PCT level of Pseudomonas aeruginosa infection group was significantly higher than that of Staphylococcus aureus infection（P〈0.01）,both groups were significantly higher than the control group（P〈0.05）.The PCT level of the general drug resistant bacteria group was significantly lower than that of the pan-resistant bacteria group（P〈0.01）,both groups were significantly higher than the control group（P〈0.05）.Conclusion The PCT level of gram-negative bacteria was significantly higher than that of gram-positive bacteria,and the higher the resistance of pathogenic bacteria,the more significant the PCT level rises.

关 键 词：铜绿假单胞菌 金黄色葡萄球菌 降钙素原 耐药性 

分 类 号：R446.5[医药卫生—诊断学]