调控神经干细胞迁移的分子网络机制与潜在药物靶点  

The molecular mechanisms and potential drug targets to regulate neural stem cells migration

作　　者：邓冉 李舒冉 刘庆山 

机构地区：[1]中央民族大学药学院,北京100081

出　　处：《国际药学研究杂志》2017年第10期914-917,共4页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(81473424;81774006)

摘　　要：神经干细胞(NSC)治疗是目前改善脑卒中和神经退行性疾病等症状的主要手段。本文结合国内外研究进展,系统分析了趋化因子、脑源性神经营养因子、血管内皮生长因子等促NSC迁移的关键分子靶标,阐明PI3K/Akt、MAPK/ERK、JAK/STAT等通路间相互关系和重要节点,有助于理解促NSC迁移药物的分子网络机制,为研发促NSC迁移的创新药物提供靶点和思路。At the moment,neural stem cells（NSC）therapy is one of the main means to improve stroke and neurodengenerative disease. This paper analyses the key molecular targets that promote NSC migration,such as chemokines,brain-derived neurotrophic factor and vascular endothelial growth factor,and clarifies the relationships as well as important nodes between pathways,like PI3 K/Akt,MAPK/ERK,and JAK/STAT. It is helpful to understand the molecular network mechanisms of NSC migration and provide ideas and targets to design creative drugs to promote NSC migration.

关 键 词：神经干细胞 迁移 细胞因子 信号通路 药物靶点 

分 类 号：R91[医药卫生—药学]