Vascular protection by high-density lipoprotein-associated sphingosine-1- phosphate  

作　　者：Xi WANG Fan WANG 

机构地区：[1]Department of Geriatric Cardiology, Chinese PLA General Hospital Beijing, 100853, China

出　　处：《Journal of Geriatric Cardiology》2017年第11期696-702,共7页老年心脏病学杂志（英文版）

摘　　要：Epidemiological studies and animal experiments have consistently demonstrated cardiovascular protection by high-density lipoprotein （HDL）. Findings from a growing number of studies further indicate that sphingosine-l-phosphate （S1P） mediates many of the beneficial effects of HDL on the cardiovascular system, including vasodilatation, angiogenesis, maintenance of endothelial barrier function, and protec- tion against atherosclerosis and ischemiaJreperfusion injury. In this review, we summarize the most recent literature investigating the effects of HDL-S 1 P on cardiovascular health and highlight potential opportunities for clinical translation of these findings.

关 键 词：APOM HDL-associated S1P Vascular function 

分 类 号：Q513[生物学—生物化学] TQ126.35[化学工程—无机化工]