犀角散加味对乙型肝炎病毒相关慢加急性肝衰竭前期胃肠激素的影响  

The clinical research of Rhinoceros horn powder treating HBV associated chronic acute liver failure in early stage

作　　者：林晖明[1] 尹燕耀[1] 林云华[1] 万勇[1] 宗亚力[1] LIN Hui-min ,YIN Yan-yao ,LIN Yun-hua ,WAN Yong ,ZONG Ya-li(Department of Integrated Medicine, Ninth Hospital of Nanchang, Nanchang 330002,China)

机构地区：[1]南昌市第九医院中西医结合肝病科,江西南昌330002

出　　处：《中国中西医结合消化杂志》2017年第12期955-957,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家临床重点专科建设项目经费资助(No:国卫医发[2013]42号);2014年江西省科技计划项目(No:20141BDH80031);2013年江西省卫生厅中医药科研计划(No:2013A169)

摘　　要：[目的]从胃肠道激素的角度探讨犀角散加味对乙型肝炎病毒(HBV)相关慢加急性肝衰竭前期的作用机制。[方法]将75例HBV相关慢加急性肝衰竭前期患者随机分为试验组与对照组,对照组予内科常规治疗,试验组在内科常规治疗基础上加用犀角散加味。用药2周观察患者胃肠激素水平变化,统计患者肝衰竭的发生率。[结果]犀角散加味治疗HBV慢加急性肝衰竭前期患者能够升高血清P物质(SP)及胃动素(MTL)水平,下调一氧化氮(NO)水平,降低肝衰竭发生率。[结论]犀角散加味可调整肝衰竭前期患者体内胃肠激素水平,阻断肝衰竭前期进展。[Objective]To investigate the effects of Rhinoceros horn powder on gastrointestinal hormone of HBV associated chronic acute liver failure in early stage.[Methods]75 patients with HBV associated chronic acute liver failure in early stage were divied into experimental group and the control group.The control group was given internal medicine treatment.On the basis of the control group,the experimental group were treated with modified oral Rhinoceros horn powder.The gastrointestinal hormone was tested in 2 weeks,and the incidence of liver failure was observed.[Results]Rhinoceros horn powder up-regulated the level of SP and MTL,down-regulated the level of NO,and reduced the incidence of liver failure.[Conclusion]Rhinoceros horn powder could improve clinical effects of HBV associated chronic acute liver failure in early stage.The mechanism might be related to regulating the contents of gastrointestinal hormone and improving gastrointestinal motility.

关 键 词：胃肠激素 犀角散加味 慢加急性肝衰竭前期 临床研究 

分 类 号：R575.1[医药卫生—消化系统]