降钙素原、超敏C-反应蛋白和纤维蛋白原在糖尿病足感染患者中的变化  

The Expression Changes Among Procalcitonin. High-sensitivity C Reactive Protein and Fibrinogen in Patients with Diabetic foot Infections

作　　者：徐升强[1] 陈峻[1] 詹燏[2] 

机构地区：[1]武汉市第一医院检验科,武汉430022 [2]武汉市中心医院检验科,武汉430014

出　　处：《血栓与止血学》2018年第1期23-25,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨糖尿病足感染(DFI)患者血清降钙素原(PCT)及血浆超敏C-反应蛋白(hs-CRP)、纤维蛋白原(Fbg)的水平变化及临床意义。方法选取2015年11月~2016年10月本院内分泌科收治的糖尿病足(DF)患者55例,依据是否存在足部感染分为糖尿病足合并感染组(29例)和糖尿病足未合并感染组(26例),同时选取26例患有糖尿病但未合并DF患者为对照组。采用荧光定量法检测患者血清PCT水平,采用免疫比浊法检测患者血浆hs-CRP水平,采用凝固法检测患者血浆Fbg水平。结果 DFI组患者的PCT、hs-CRP及Fbg水平显著高于对照组(P<0.01);DFI组患者的PCT和Fbg水平显著高于DF未合并感染组,差异有统计学意义(P<0.01);DFI组患者的hs-CRP水平显著高于未合并感染组,差异有统计学意义(P<0.05);DF未合并感染组患者的PCT、hs-CRP和Fbg水平显著高于对照组,差异有统计学意义(P<0.05)。经相关性分析,感染组患者PCT与Fbg水平与未合并感染组患者呈显著正相关(r=0.751,P<0.01),hs-CRP与Fbg水平与未合并感染组患者也呈显著正相关(r=0.383,P<0.01)。结论糖尿病患者无论是否存在糖尿病足均应积极检测血清PCT、血浆hs-CRP和Fbg水平,并早期进行抗感染及抗凝治疗,以保障周围血管血供。Objective To investigate the expression changes and their relationship among procalcitonin （ PCT）, high- sensitivity C reactive Protein （ hs- CRP）, and fibrinogen （Fbg） in patients with the diabetic foot （DF） infections. Methods A total of 55 DF patients in our hospital from November 2015 to October 2016 were selected as study subjects, and divided into the infected group （29 cases ）and non-infection group （26 cases）, depending on whether the presence of foot-infections,while 26 cases with diabetes unincorporated DFI were selected as the control group. PCT, hs- CRP and Fbg levels were detected by immune-fluorescence, immunoturbidimetry and plasma coagulation, respectively. Results PCT, hs- CRP and Fbg levels in the infected group were significantly higher than those in the control group（ P 〈 0.01 ） ;PCT and Fbg levels in the infected group were significantly higher than those in the non-infection group（P 〈 0. 01 ） ;hs-CRP levels in the infected group were higher than those in the non-infection group（P 〈 0.05 ） ;PCT,hs-CRP and Fbg levels in the non-infection group were higher than those in the control group （P 〈 0. 05 ）. By correlation analysis, PCT and Fbg in the infected group had significantly correlated with the non-infection group （r = 0. 751, P 〈 0.01 ）, and hs-CRP and Fbg in the infected group had significantly correlated with the non-infection group （r = 0. 383,P 〈 0. 01 ）too. Conclusion Patients with DFI should detect PCT, hs-CRP and Fbg levels to carry out early anti-infective and anticoagulant therapy.

关 键 词：糖尿病足 感染 超敏C-反应蛋白 降钙素原 纤维蛋白原 

分 类 号：R587.1[医药卫生—内分泌]