支气管哮喘-慢性阻塞性肺疾病重叠综合征患者呼出气冷凝液和血清8-isoPG、MPO、LTB4、IL-6的测定及临床意义  

Clinical significance of exhaled breath condensate and serum 8-iso PG MPO,LTB4 and IL-6 in patients with bronchial asthma and chronic obstructive pulmonary disease overlap syndrome

作　　者：熊小明[1] 童国强[1] 付云杰 陈雪礼[2] 项琪 计玉冰 程瑞明[1] 

机构地区：[1]九江市第一人民医院呼吸内科,江西九江332000 [2]九江市第一人民医院检验科,江西九江332000

出　　处：《实用医学杂志》2018年第4期649-652,共4页The Journal of Practical Medicine

基　　金：江西省卫生计生委科技计划基金(编号:20164031)

摘　　要：目的探讨呼出气冷凝液(EBC)、血清中炎症标志物对支气管哮喘-慢性阻塞性肺疾病重叠综合征(ACOS)患者的临床意义。方法选择在我院诊治的慢性气道炎症性疾病患者,随访进入稳定期后纳入临床实验,ACOS患者18例,支气管哮喘(哮喘)22例,慢性阻塞性肺疾病(慢阻肺)24例,同期20例健康非吸烟者为对照组;检测EBC和血清8-异前列腺素(8-iso PG)等炎症因子浓度进行比较分析。结果 ACOS组血清、EBC中8-iso PG浓度均显著高于健康对照组,ACOS组EBC中8-iso PG浓度显著高于哮喘组、慢阻肺组,差异均有统计学意义(P<0.05);EBC中8-iso PG水平与年龄、吸烟指数、体重、FEV1值无明显相关性(P>0.05)。结论 8-iso PG等炎症因子参与了ACOS患者气道炎症过程,EBC中8-iso PG可能具有潜在的鉴别ACOS生物标志物价值,值得进一步研究。Objective To investigate the clinical significance of biochemical markers in EBC and serum in patients with bronchial asthma and chronic obstructive pulmonary disease overlap syndrome （ACOS）. Methods We selected Patients with chronic airway inflammatory diseases in our hospital, These patients underwent clinical trial after the stable phase, including 18 ACOS patients, 22 asthma patients, 24 COPD patients and 20 healthy non-smokers in the same period. 8-isoPG and other inflammatory factors levels in EBC and serum were measured in the selected patients. A comparative analysis was performed. Results The levels of EBC 8-isoPG in the ACOS group were significantly higher than those in the healthy control group, The levels of serum and EBC 8-isoPG in the ACOS group were significantly higher than the asthma group and the COPD group （P 〈 0.05）. The level of 8-isoPG in EBC was not related to age, smoking index, weight, and FEVlvalue（P 〉 0.05）. Conclusions Inflam- matory factors including 8-isoPG, are involved in chronic inflammation in lung tissues of patients with ACOS. 8-isoPG in EBC may have potential value in identifying ACOS from COPD and asthma as biomarkers and deserve further study.

关 键 词：支气管哮喘-慢性阻塞性肺疾病重叠综合征 呼出气冷凝液 8-异前列腺素 

分 类 号：R562.25[医药卫生—呼吸系统] R563.9[医药卫生—内科学]