抑制素免疫对动物卵泡发育的影响  

Effects of inhibin immunization on follicular development in animals

作　　者：阳美霞 张虹亮 张羽芳 王水莲[1] 

机构地区：[1]湖南农业大学动物医学院

出　　处：《中兽医医药杂志》2018年第1期32-34,共3页Journal of Traditional Chinese Veterinary Medicine

基　　金：国家自然科学基金项目(31672507)

摘　　要：抑制素主要是由卵巢颗粒细胞和睾丸支持细胞分泌的一类异二聚体蛋白质激素,具有反馈性抑制垂体前叶释放促卵泡激素的作用。抑制素免疫能通过中和内源性抑制素,降低其对垂体的负反馈,增加促卵泡激素的分泌,促进卵泡发育的作用。本文综述了抑制素免疫对卵泡数目与直径、颗粒细胞增殖和卵母细胞成熟的影响,为抑制素免疫的研究和临床应用提供理论依据。Inhibin,a dimeric glycoprotein primarily secreted by the ovarian granular cells and testicular Sertoli cells,is capable of inhibiting follicle stimulating hormone（FSH）release from the anterior pituitary in a feedback way. Moreover,it could regulate the follicular development. Inhibin immunization technology could increase FSH secretion through neutralizing the inhibitory effect on endogenous inhibin and attenuating its negative feedback on the pituitary. The authors reviews the advance of inhibin immunization on the number and diameter of follicles,granular cell proliferation and oocyte maturation,which can provide a theoretical basis for the further study and clinical application of inhibin immunization technology.

关 键 词：抑制素免疫 卵泡数 颗粒细胞 卵母细胞 

分 类 号：S852.1[农业科学—基础兽医学]