胰升糖素样肽1通过特定脑神经核团调节食欲  

Glucagon like peptide-1 regulates appetite via specific nuclei in the central nervous system

作　　者：文松 萧文泽 金建兰 龚敏 周里钢 

机构地区：[1]复旦大学附属浦东医院内分泌科,上海201399

出　　处：《中华内分泌代谢杂志》2018年第2期174-180,共7页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金面上项目（编号81370932）

摘　　要：胰升糖素样肽1（glucagon like peptide-1, GLP-1）是一种由肠道分泌的肽类激素。GLP-1的发现源于上世纪60年代＂肠促胰素＂现象的发现。GLP-1除具有降低血糖的作用，还能保护胰腺，改善心血管结局，改变食欲，降低体重。GLP-1控制进食的机制目前还不明确，推测中枢神经系统起了主要的作用。本综述主要从以下几方面论述中枢神经系统在GLP-1调节食欲中的作用：（1）与食欲调节有关的脑神经核团；（2）与血糖调节有关的脑神经核团；（3）与进食奖赏行为相关的脑神经核团；（4）与进食相关的肽类物质及GLP-1的作用；（5）表达GLP-1受体的脑神经核团调节进食的作用.[ Summary ] Glucagon like peptide-1 （ GLP-1 ） is a category of peptide secreted by intestine. The finding of GLP-1 was originated from the observation of ＂Incretin＂ phenomenon in 1960s. Besides lowering plasma glucose, GLP-1 can protect pancreas, improve cardiovascular outcome, and play a role in regulating appetite, as well as lower body weight. Given that food intake regulation mechanism modulated by GLP-1 remains uncertain, it is postulated that the central nervous system has played a vital role in this mechanism. In the present review, we focused on the following aspects about central nervous system＇s role in GLP-1 ＇s regulation of appetite ： （ 1 ） The brain nuclei related to appetite regulation; （2） The brain nuclei related to blood glucose regulation; （3） The brain nuclei related to food intake reward behavior; （4） the role of food-related peptides and GLP-1 ; （5） How the GLP-1 receptor expression nuclei regulates the food intake

关 键 词：胰升糖素样肽1 进食 下丘脑 食物奖赏中枢 

分 类 号：R338[医药卫生—人体生理学]