二甲基蓝介导的光动力抗菌疗法对AIDS合并口腔白色念珠菌病的疗效观察  

Dimethylmethylene blue mediated photodynamic therapy for the treatment of AIDS combined with oral Candida albicans infection

作　　者：赵玥 覃金梅 黄力毅[1] 李庆妮[1] 全昌圆 甄秀梅[1] 杨倩 李峥[1] 

机构地区：[1]广西医科大学第一附属医院感染性疾病科,南宁530021

出　　处：《广西医科大学学报》2018年第2期178-180,共3页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.81260239;No.81472002);广西科技攻关项目(No.桂科攻1355005-1-2);广西自然科学基金资助项目(No.2016GXNSFAA380312)

摘　　要：目的:探讨二甲基蓝(DMMB)介导的光动力抗菌疗法(APDT)在艾滋病(AIDS)合并口腔白色念珠菌感染患者中的治疗效果。方法:选取60例确诊为AIDS合并口腔白色念珠菌病的住院患者为治疗对象,随机分为研究组(42例)和对照组(18例)。研究组行DMMB介导的APDT治疗,对照组给予5%碳酸氢钠含漱联合制霉素局部点涂患处。观察两组治疗前、后白色念珠菌菌数的变化及治疗总有效率。结果:研究组和对照组白色念珠菌清除率分别为73.00%和52.00%(P<0.05),两组治疗后白色念珠菌菌数均较治疗前明显减少,且研究组减少更为明显,差异均有统计学意义(均P<0.05)。研究组和对照组对口腔白色念珠菌病的治疗总有效率分别为95.24%和61.11%,差异有统计学意义(P<0.05)。结论:DMMB介导的APDT对AIDS患者合并口腔白色念珠菌感染有明显的疗效及较好的杀菌作用。Objective： To investigate the effect of dimethylmethylene blue （DMMB） mediated antimicrobial photodynamic therapy （APDT） on acquired immunodeficiency syndrome （AIDS） combined with oral Candida albicans infection. Methods： Sixty patients with AIDS combined with oral Candida albicans infection were se- lected, and randomly divided into a research group （n=42） and a control group （n= 18）. The patients in the re- search group received DMMB mediated APDT, and those in the control group received 5% sodium bicarbonate for gargle combined with external application of nystatin. The number of C. albicans colonies was recorded be- fore and after treatment. Results： The clearance rate of C. albicans were 73. 00% and 52. 00% in the research group and the control group, respectively. The total effective rate were 95. 24% and 61. 11% in the research group and the control group, respectively. There were significant differences in the clearance rate of C. albicans and the total effective rate between the two groups （P〈 0. 05）. Conclusion： DMMB mediated APDT was effec- tive in the treatment of AIDS combined with oral C. albicans infection.

关 键 词：光动力抗菌治疗 二甲基蓝 口腔白色念珠菌感染 艾滋病 

分 类 号：R512.91[医药卫生—内科学] R781.5[医药卫生—临床医学]