毛兰素抗肿瘤活性研究进展  

Research progress of antitumor activity of erianin

作　　者：张小莉[1] 安云鹤[1] 程小艳[1] 钱嘉林[1] 安雷雷 李俊博[1] 武会娟[1] 

机构地区：[1]北京市理化分析测试中心,北京100089

出　　处：《分析仪器》2018年第1期212-216,共5页Analytical Instrumentation

摘　　要：毛兰素是从石斛中提取的天然产物,近年来发现毛兰素在体外和体内表现出抗癌活性,诱导多种肿瘤细胞生长抑制。目前报道的毛兰素抗肿瘤效应与多个信号通路相关。通过激活细胞凋亡的内部线粒体途径和死亡受体介导的外部凋亡途径诱导凋亡;通过ROS/JNK信号通路诱导细胞周期G2/M期停滞,凋亡和自噬;通过调节促迁移蛋白和迁移抑制蛋白的表达抑制肿瘤细胞的迁移;通过阻断JAK2/STAT3的磷酸化抑制血管生成等。本文针对抗肿瘤活性的研究进行简要综述。Erianin is a natural product extracted from dendrobium.In recent years,it has been found that erianin exhibits antitumor activity in both vitro and vivo by inducing the growth inhibition of various tumor cells.The currently reported antitumor effects of erianin are associated with multiple signaling pathways.Apoptosis is induced through the external apoptotic pathways and the internal mitochondrial pathway;Cell cycle G2/M arrest,apoptosis and autophagy are induced through ROS/JNK signaling pathway;The migration of tumor cells is inhibited by erianin through regulating the expression of migration protein;Angiogenesis is inhibited by blocking phosphorylation of JAK2/STAT3.To sum up,the recent advances in the study of antitumor activity of erianin were reviewed in this article.

关 键 词：毛兰素 抗肿瘤活性 研究进展 

分 类 号：R285[医药卫生—中药学]