非致密化心肌厚度/致密化心肌厚度比值与心肌致密化不全患儿预后的相关性分析  

Correlation between N/C ratio and prognosis in children with noncompaction of venricular myocardium

作　　者：付佳 张勇[1] 彭静[1] 夏琨[1] 王丹丹[1] 蔡珊珊[1] 刘婧 

机构地区：[1]华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)心内科,武汉430000

出　　处：《临床心血管病杂志》2018年第2期166-168,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨舒张末期非致密化心肌厚度/致密化心肌厚度比值(N/C)与心肌致密化不全(NVM)患儿预后的相关性。方法:对2015-01-2017-04在我院心内科收治的25例NVM患儿利用超声心动图对其进行定性及定量分析,同时完善心脏MRI检查,得到N/C比值并根据其大小将其分为4个区间:1.4~4,4~6,6~8,8~10。对所有入组患儿行24h动态心电图检查,分析其心律失常发生情况。根据不同N/C区间患儿治疗前后N末端脑钠肽前体(NT-proBNP)水平变化来判断患儿预后,并探讨不同N/C区间患儿心律失常发生情况。结果:25例NVM患儿治疗后NT-proBNP与左室射血分数(LVEF)较治疗前改善明显;N/C比值越高,预后越差,且有患严重心律失常的风险。结论:NVM在经积极内科治疗后心功能评价指标NT-proBNP与LVEF可得到改善;N/C比值越高,预后越差,有发生严重心律失常的可能。Objective：To explore the correlation between the ratio of thickness of non compact myocardium and thickness of compacted myocardium（N/C）and the prognosis in children with noncompaction of venricular myocardium（NVM）.Method：Twenty-five children with NVM were admitted to our hospital from 2015 January to 2017 April.Qualitative and quantitative analysis was used by echocardiogram and cardiac MRI.All patients were divided into four groups according to the N/C ratio：1.4-4,4-6,6-8 and 8-10.The occurrence of arrhythmia was recorded by 24 hour Holter.Among the patients with different N/C ratios,NT-proBNP levels before and after treatment were compared and used to determine the prognosis,then the incidence of arrhythmia was compared.Result：In 25 children with NVM,levels of left ventricular ejection fraction（LVEF）and NT-proBNP were improved significantly after treatment.The higher the N/C ratio,the worse the prognosis and the higher risk of severe arrhythmia.Conclusion：In patients with NVM,cardiac function evaluation indexes NT-proBNP and LVEF can be improved after treatment.The higher the N/C ratio,the worse the prognosis and the more serious arrhythmias.

关 键 词：心肌致密化不全 心功能不全 心律失常 N末端脑钠肽前体 左室射血分数 

分 类 号：R542.2[医药卫生—心血管疾病]