高效抗HIV治疗与甲状腺疾病的相关性探讨  

Correlation between highly active anti-HIV therapy and thyroid diseases

作　　者：徐杰[1] 高楚淇 白娟[3] 

机构地区：[1]延安大学附属医院,延安716000 [2]西安交通大学第一附属医院 [3]延安市人民医院

出　　处：《内科急危重症杂志》2017年第6期492-494,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:探讨高效抗HIV治疗与甲状腺疾病的相关性。方法:收集2014~2015年之间艾滋病患者111例,分为2组:试验组62例,采用高效抗逆转录病毒疗法(HAART)治疗。对照组49例,未运用HAART治疗。测定2组患者CD4+T淋巴细胞、TSH、FT_4、anti-TPO等生化指标,以评估相关性。结果:试验组患者亚临床甲减的患病率显著高于对照组(χ~2=3.965,OR=2.781,95%CI:0.981~7.884,P=0.046)。其中,试验组患者使用司他夫定后亚临床甲减的患病率(30.00%,6/20)显著高于未使用司他夫定的患者(4.76%,2/42)(χ~2=5.420,OR=3.680,95%CI:1.165~11.621,P=0.018)。结论:HAART能显著影响患者的甲状腺疾病患病率,其中司他夫定是亚临床甲减的显著风险因素。Objective：To study the correlation between highly active anti-HIV therapy and thyroid diseases. Methods：111 AIDS patients were collected between 2014-2015,and divided into experimental group（n = 62,HAART treatment） and control group（n = 49,no HAART treatment）,and the data for demographic characteristics and biochemical indicators of CD4 ＋ T lymphocytes,TSH,FT_4,anti-TPO,etc. were measured,and the correlation was assessed. Results：The prevalence of subclinical hypothyroidism in experimental group was significantly higher than in control group（χ~2= 3. 965,OR =2. 781,95% CI：0. 981-7. 884,P = 0. 046）. Among them,the prevalence of subclinical hypothyroidism in experimental group using stavudine（20. 00%,6/30） was significantly higher than that in the patients without using stavudine（4. 76%,2/42）（χ~2= 5. 420,OR = 3. 680,95% CI：1. 165-11. 621,P = 0. 018）. Conclusion：HAART could significantly influence the prevalence of thyroid diseases,and stavudine was a significant risk factor for subclinical hypothyroidism.

关 键 词：高效抗逆转录病毒 HIV 甲状腺疾病 相关性 

分 类 号：R581[医药卫生—内分泌]