过氧化物酶增殖物激活受体α/过氧化物酶增殖物激活受体γ和痛觉过敏关系的研究进展  

Research advances on the relationship between peroxisome proliferator-activated receptor α/ peroxisome proliferator- activated receptor γ and hyperaigesia

作　　者：张佐霞[1] 刘玥[1] 马正良[1] 

机构地区：[1]南京大学医学院附属鼓楼医院麻醉科,210008

出　　处：《国际麻醉学与复苏杂志》2018年第1期66-69,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金（81471129,81171048）;江苏省医学重点学科项目（XK201140）

摘　　要：背景过氧化物酶增殖物激活受体（peroxisome proliferator-activated receptors,PPARs）属于配体依赖性激活的核受体转录因子超家族,它包括3种亚型,即PPARα、PPARβ/δ和PPARγ,主要参与体内细胞增殖与分化、物质能量代谢以及炎症反应.近年研究发现：特异性激活PPARα/PPARγ后,可以有效预防痛觉过敏的发生发展.目的 探讨PPARα/PPARγ在痛觉过敏发生发展中的作用.内容对PPARα/PPARγ与痛觉过敏的关系进行综述.趋向为痛觉过敏的防治提供新思路、新办法.Background Peroxisome proliferator-activated receptors （PPARs） are ligand-activated transcription factors belong to a nuclear hormone receptor superfamily, containing three family members： PPARα, PPARβ/δ and PPARγ. PPARs play a critical physiological role in cell proliferation and differentiation, substance metabolism, energy homeostasis and inflammatory response. Recently, PPARα/PPARγ agonists were reported preventing the occurrence and development of hyperalgesia. Objective To investigate the role of PPARα/PPARγin the occurrence and development of hyperalgesia. Content Reviewing the relationship between PPARα/PPARγand hyperalgesia. Trend To provide new methods for prevention and treatment of hyperalgesia.

关 键 词：过氧化物酶增殖物激活受体 痛觉过敏 

分 类 号：R402[医药卫生—临床医学]