早期帕金森病患者脑葡萄糖代谢网络模式的18F-FDGPET显像研究  

The Study on Metabolic Brain Networks of Glucose in Patients with early Parkinson's Disease by ^(18)F-FDG PET Imaging

作　　者：李修明 宋炯 朱毓华 鲍伟奇 管一晖 谭海波 

机构地区：[1]复旦大学附属华山医院PET中心

出　　处：《中国医学计算机成像杂志》2018年第1期88-91,共4页Chinese Computed Medical Imaging

基　　金：上海市自然科学基金项目No.15ZRl405400上海市卫生与计划生育委员会科研课题项目No.201440596上海市卫生与计划生育委员会中医药科研课题项目No.2014JP004A

摘　　要：目的:用18F-脱氧葡萄糖正电子发射断层显像(^(18)F-FDG PET)显示早期帕金森病(PD)患者脑葡萄糖代谢变化的特点及其异常脑代谢网络模式(PDRP),为PD早期诊断和鉴别诊断奠定基础。方法:对早期PD(H-Y Ⅰ~Ⅱ级)组10例、年龄及性别匹配的健康对照者10例进行^(18)F-FDG PET显像,应用参数图分析法(SPM)进行数据分析,比较两组受试者脑内葡萄糖代谢变化的差异和特点。对上述脑PET图像进行基于体素的脑地形剖面分级(TPR)运算,获得相应的PDRP表达值。结果:与健康对照组比较,早期PD患者在壳核、苍白球、丘脑、脑桥、小脑和初级运动皮质区均表现为葡萄糖代谢明显增强。PD组的PDRP表达值为1.512±0.631,对照组的PDRP表达值为0.000±0.548,前者明显高于后者(t=10.731,P<0.001)。结论:基于^(18)F-FDG PET显像得到的PDRP可以有效区分早期PD患者和健康对照者,有助于PD的早期诊断。Purpose： To assess the changes of brain glucose metabolism in early PD and validate PD-related pattern （PDRP） network as a measurement of early PD by 18F-FDG PET imaging. Methods： Ten early PD patients and 10 healthy controls were recruited to perform resting-state brain 18F-FDG PET imaging. Statistical Parametric Mapping （SPM） was used to investigate the metabolic changes and characteristics of glucose in the brain. To obtain the PDRP, principal component analysis （PCA） was used. Results： Compared with the control group, hyper- metabolism was observed in putamen, globus pallidus, thalamus, pons, cerebellum and primary motor cortex in early PD group. The value of PDRP expression in PD group （1.512±0.631） was significantly higher than that of healthy eontrols（0.000±0.548;t=10.731, P〈0.001）. Conclusion： The PDRP based on 18F-FDG PET imaging is useful for identification of early PD patients from healthy controls, and it may help the early diagnosis of PD.

关 键 词：帕金森病 脑 代谢 体层摄影术 发射型计算机 脱氧葡萄糖 

分 类 号：R445.6[医药卫生—影像医学与核医学]