美托洛尔联合小剂量地高辛治疗慢性心力衰竭合并快室率房颤的临床评价  

Clinical evaluation of metoprolol combined with low-dose digoxin in the treatment of chronic heart failure complicated with fast ventricular rate atrial fibrillation

作　　者：黄思兵[1] 

机构地区：[1]惠州市第一人民医院心内科,516100

出　　处：《中国现代药物应用》2018年第5期7-8,共2页Chinese Journal of Modern Drug Application

摘　　要：目的评价慢性心力衰竭合并快速心室率(快室率)心房颤动(房颤)应用美托洛尔联合小剂量地高辛治疗的效果。方法 98例慢性心力衰竭合并快室率房颤患者,根据随机数字表法分为对照组和治疗组,各49例。对照组给予地高辛治疗,治疗组给予美托洛尔联合小剂量地高辛治疗。比较两组患者临床疗效、心功能、临床指标及不良反应发生情况。结果治疗组治疗总有效率(95.9%)高于对照组(81.6%),差异有统计学意义(P<0.05)。治疗组各心功能指标均优于对照组,各临床指标低于对照组,差异有统计学意义(P<0.05)。治疗组不良反应发生率为6.1%(3/49),对照组不良反应发生率为4.1%(2/49),两组不良反应发生率比较差异无统计学意义(P>0.05)。所有不良反应经处理后,均可有效缓解。结论在慢性心力衰竭合并快室率房颤患者临床治疗中,采用美托洛尔联合小剂量地高辛疗效显著,既可改善心功能,又可缓解临床指标,同时不良反应经处理后均可有效缓解,安全性较高。Objective To evaluate the effect of metoprolol combined with low-dose digoxin in the treatment of chronic heart failure complicated with fast ventricular rate atrial fibrillation.Methods A total of 98 patients with chronic heart failure complicated with fast ventricular rate atrial fibrillation were divided by random number table method into control group and treatment group,with 49 cases in each group.The control group was treated with digoxin,and the treatment group was treated with metoprolol combined with low-dose digoxin.Comparison were made on clinical efficacy,cardiac function,clinical indicators and occurrence of adverse reactions between two groups.Results The treatment group had higher total treatment effective rate（95.9%） than the control group（81.6%）,and the difference was statistically significant（P〈0.05）.The treatment group had better cardiac function indicators than the control group,and lower clinical indicators than the control group.Their difference was statistically significant（P〈0.05）.The treatment group had incidence of adverse reactions as 6.1%（3/49）,which was 4.1%（2/49） in the control group.Both groups had no statistically significant difference in incidence of adverse reactions（P〈0.05）.All adverse reactions could be effectively relieved after treatment.Conclusion During the treatment of chronic heart failure complicated with fast ventricular rate atrial fibrillation,combination of metoprolol and low-dose digoxin can not only improve cardiac function,but also relive clinical indicators.Meanwhile,adverse reactions can be effectively relieved after treatment with high safety.

关 键 词：慢性心力衰竭 快速心室率 心房颤动 美托洛尔 小剂量地高辛 

分 类 号：R541.6[医药卫生—心血管疾病] R541.75[医药卫生—内科学]