基于Gd的造影剂在T_1加权MRI上的研究进展  

Recent advance of Gd-based contrast agents on T_1-weighted MRI

作　　者：王凯丽 田启威[1] 杨仕平[1] 

机构地区：[1]上海师范大学生命与环境科学学院,上海200234

出　　处：《上海师范大学学报（自然科学版）》2018年第1期78-89,共12页Journal of Shanghai Normal University(Natural Sciences)

基　　金：国家自然科学基金(21601124;21671135)

摘　　要：磁共振成像(MRI)由于具有较深的组织穿透能力和高的空间分辨率,已成为临床医学常规使用的诊断工具之一.MRI造影剂能有效提高病灶区域和周围组织的对比度,被广泛应用于MRI医疗诊断.基于Gd的MRI造影剂,由于其能最大程度地加速纵向弛豫,产生更明亮的图像,使得该类造影剂被科研工作者不断开发和研究.综述了Gd造影剂在T1加权MRI上的最新研究进展.Magnetic resonance imaging（MRI） has become one of the most common diagnostic tools in clinical medicine due to its deep tissue penetration and high spatial resolution. MRI contrast agent has been widely used in MRI medical diagnosis because it can effectively improve the contrast effect of the lesion area and surrounding tissue. Since Gd-based MRI contrast agents can accelerate the longitudinal relaxation to the maximum extent and produce brighter images,they have been deeply developed and studied by researchers. Thus,the advance of the Gd-based contrast agents on T1 weighted MRI was introduced in this review.

关 键 词：磁共振成像 钆 钆配合物 钆纳米材料 T1-T2双模式成像 

分 类 号：O614.24[理学—无机化学]