3-季碳氧化吲哚合成及抗肿瘤活性研究进展  

The Progress on the Synthesis and Anti-tumor Activities of 3-quaternary Carbon Oxindoles

作　　者：杨俊 李楠柯 梁光平 丁丽娜[1] 陈东林[1] 聂昌平[1] 刘雄利[2] 周英[2] 

机构地区：[1]遵义医药高等专科学校,贵州遵义563006 [2]贵州大学贵州省中药民族药创制工程中心,贵州贵阳550025

出　　处：《铜仁学院学报》2018年第3期30-37,共8页Journal of Tongren University

基　　金：贵州省科技合作计划项目(黔科合LH字[2016]7418号);贵州省科技合作计划项目(黔科合LH字[2015]7578号)

摘　　要：3-季碳氧化吲哚衍生物由于其特殊的生物活性,一直是有机化学家合成的热点,主要综述了合成3-季碳氧化吲哚的方法:C-H活化、Morita-Baylis-Hillman反应、Micheal加成反应、3+2环加成、aldol反应、mannich反应、串联反应、共轭加成,并对3-季碳氧化吲哚的抗肿瘤活性进行介绍。3-quaternary carbon oxide derivatives have been the chemical synthesis of hot spots because of its special biological activity. This article describes the synthetic methods, such as C-H activations, Mortia-Baylis-Hillman reactions, Michael addition reactions, 3＋2 cycloadditions, aldol reactions,and mannich reactions, tandem reactions, as well as a conjugate addition strategy. And their anti-tumor activity is also discussed in this paper.

关 键 词：3-季碳氧化吲哚 抗肿瘤活性 

分 类 号：O626[理学—有机化学]