薄芝糖肽注射液、注射用血塞通联合水蛭免煎颗粒治疗椎-基底动脉供血不足性眩晕的临床观察  

Clinical observation of Bozhi glycopeptides injection,Xuesaitong for injection and hirudo in treating vertigo caused by vertebrobasilar ischemia

作　　者：任树林 贺佩瑾 

机构地区：[1]河北省沽源县人民医院内科,河北沽源076650 [2]河北省张家口市崇礼区中医院内科,河北崇礼076350

出　　处：《河北中医》2018年第2期196-200,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：张家口市科学技术和地震局科学技术研究与发展计划项目(编号:1521027D)

摘　　要：目的观察薄芝糖肽注射液、注射用血塞通联合水蛭颗粒治疗椎-基底动脉供血不足性眩晕的临床疗效。方法将86例椎-基底动脉供血不足性眩晕患者随机分为2组。对照组43例予盐酸氟桂利嗪胶囊治疗;治疗组43例予薄芝糖肽注射液、注射用血塞通联合水蛭免煎颗粒治疗。2组均2周为1个疗程,2个疗程后统计疗效,并比较2组治疗前后眩晕症状评分情况;比较2组治疗前后双侧椎动脉与基底动脉血液流速变化情况,包括舒张末期流速(Vd)、收缩期峰流速(Vs)及平均流速(Vm);比较2组治疗前后血液流变学指标变化情况,包括全血黏度(高切)、全血黏度(低切)、血浆黏度、红细胞比容及纤维蛋白原。结果2组治疗后眩晕症状评分与本组治疗前比较均明显降低(P<0.05),且治疗组治疗后眩晕症状评分较对照组治疗后降低更明显(P<0.05);治疗组总有效率88.4%,对照组总有效率72.1%,治疗组疗效优于对照组(P<0.05);治疗组治疗后双侧椎动脉及基底动脉血液流速各指标与本组治疗前比较均明显增加(P<0.05),且各指标均高于对照组治疗后水平(P<0.05),对照组治疗后仅左侧椎动脉Vm及右侧椎动脉Vd、Vm水平较治疗前明显增加(P<0.05);治疗组治疗后血液流变学指标与本组治疗前比较均明显降低(P<0.05),且各指标均低于对照组治疗后水平(P<0.05),对照组治疗前后血液流变学指标比较差异均无统计学意义(P>0.05)。结论薄芝糖肽注射液、注射用血塞通联合水蛭颗粒治疗椎-基底动脉供血不足性眩晕可明显提高临床疗效,改善患者眩晕症状,提高椎动脉及基底动脉血流速度,有效改善血液流变学指标,安全可靠。Objective To observe the clinical effects of Bozhi glycopeptides injection,Xuesaitong for injection and hirudo in treating vertigo caused by vertebrobasilar ischemia.Methods 86 patients with vertigo caused by vertebrobasilar ischemia were randomly divided into two groups.43 cases in control group were treated by Flunarizine hydrochloride capsules,43 cases in treatment group were treated by Bozhi glycopeptides injection,Xuesaitong for injection and hirudo.A treatment course was 2 weeks that continuously treatment for two courses in two groups.The curative effects were evaluated after 2 treatment course.The score of vertigo symptom before and after treatment were observed and compared in two groups.The changes of blood flow velocity of bilateral vertebral artery and basilar artery including the end-diastolic velocity(Vd),systolic peak velocity(Vs) and mean velocity(Vm) before and after treatment were compared in two groups.The changes of hemorheology indexes including whole blood viscosity(high shear),whole blood viscosity(low shear),plasma viscosity,hematocrit and fibrinogen before and after treatment were compared in two groups.Results The scores of vertigo symptom after treatment were significantly reduced in both groups(P < 0.05),and the reduction in treatment group were more obvious than that in control group(P <0.05).The total effective rate was 88.4% in treatment group and 72.1% in control group,and the curative effect in treatment group was better than that in control group(P <0.05).The indexes of blood flow velocity of bilateral vertebral artery and basilar artery after treatment were significantly increased in treatment group(P < 0.05),and all indexes were higher than those in control group after treatment(P < 0.05).In control group,only the Vm of the left vertebral artery and the Vd and Vm of the right vertebral artery were significantly increased(P < 0.05).The hemorheology indexes after treatment were significantly reduced in treatment group(P < 0.05),and all indexes after treatment in treatment group w

关 键 词：椎底动脉供血不足 眩晕 中药疗法 中成药 

分 类 号：R255.3[医药卫生—中医内科学] R441.2[医药卫生—中医学]