经皮椎体成形术后抗骨质疏松联合药物治疗再发脊柱椎体压缩骨折的疗效  

The effect of combined anti-osteoporosis drugs after percutaneous vertebroplasty for secondary spinal vertebral body compression fractures

作　　者：高靖濠 李茏洋 张沛东 王翠[1] 陈伯华[1] 

机构地区：[1]青岛大学附属医院骨科中心,山东266000

出　　处：《骨科临床与研究杂志》2018年第2期96-100,共5页Journal Of Clinical Orthopedics And Research

基　　金：国家自然科学基金(81772412)~~

摘　　要：目的评价经皮椎体成形术(PVP)后给予抗骨质疏松联合药物治疗再发脊柱椎体压缩骨折的疗效。方法选取2015年1月至2017年1月青岛大学附属医院采用PVP治疗的200例患者,每入选2例患者随机抽签分组,抽到1号签的患者作为对照组,抽到2号签的患者作为观察组。对照组给予常规药物治疗,观察组给予抗骨质疏松联合药物治疗。随访评价2组患者的治疗效果。结果所有患者均获得完整随访,观察组随访时间(18.4±6.3)个月,对照组随访时间(17.5±5.6)个月。末次随访时,2组患者VAS评分和Cobb角均低于术前,且观察组低于对照组(P<0.05);2组患者椎体中部高度均高于术前,且观察组高于对照组(P<0.05)。2组患者术后手术椎体骨密度均高于术前,且2组患者手术节段邻近椎体和非邻近椎体骨密度高于术前,观察组骨密度高于对照组(P<0.05)。观察组患者脊柱再发骨折发生率低于对照组,且骨质疏松症状控制率高于对照组(P均<0.05)。结论 PVP术后给予抗骨质疏松联合药物治疗对再发脊柱椎体压缩骨折疗效肯定,可减轻骨质疏松症状,提升骨密度,降低脊柱骨折的复发风险。】 Objective To evaluate the effect of combined anti-osteoporosis drugs after percutaneous ver- tebroplasty （PVP） for secondary spinal vertebral body compression fractures. Methods From January 2015 to January 2017,a total of 200 patients treated with PVP were recruited in the Affiliated Hospital of Qingdao Uni- versity, each 2 patients were randomly grouped by drawing lots, the patients with No. 1 were selected as the control group and the patients with the No. 2 as the observation group. Patients in control group were given rou-tine medicine treatment. Patients in observation group were given anti-osteoporosis and medical treatment. Follow-up and evaluation of the therapeutic effect of 2 groups were performed. Results All the patients were followed-up,the follow-up time was （18.4 ±6. 3） months of observation group and （17. 5 ±5.6） months of control group. At the final follow-up, the VAS and Cobb angles in both groups were lower than that of preopera-tion ,and the values of observation group were lower than that of the control group （P 〈 0. 05）. The height of the middle part of the vertebral body in both groups were higher than that of preoperation, and the value of observation group was higher than that of the control group （P 〈0 . 05） . Postoperative vertebral bone densities of the 2 groups were higher than that of preoperation, and the operation of the 2 groups of adjacent vertebral bodies, non adjacent vertebral bone mineral density were higher than that of preoperation （P 〈 0. 05）. The incidence rate of spinal refracture of the observation group was lower than that of the control group, and the control rate of osteoporesis was higer than that of the control group. The differences were statistically significant （al l P 〈0. 05 ） . Conclusion Combined anti-osteoporosis drug treatment after PVP for secondary spinal vertebral body compression fractures C￡in reduce the symptoms of osteoporosis and improve bone density as well as reduce

关 键 词：脊柱骨折 骨折 压缩性 骨质疏松性骨折 椎体成形术 

分 类 号：R687.3[医药卫生—骨科学]