比较万古霉素持续输注与间断输注引起肾毒性的荟萃分析  

Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion

作　　者：郑丽丽[1] 轩辕欢[1] 姜倩[1] 范芳芳[1] 姚莉[1] 赵生俊[1] 

机构地区：[1]新疆医科大学附属中医医院药学部,新疆乌鲁木齐830054

出　　处：《药学实践杂志》2018年第2期136-139,146,共5页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金(81460603)

摘　　要：目的比较万古霉素两种给药方式(持续输注与间断输注)引起的肾毒性。方法计算机检索Embase、PubMed、The Cochrane Register of Controlled Trials和CBM、CNKI、万方数据库。采用Cochrane协作网提供的Revman5.2软件进行Meta分析。结果共纳入2篇随机对照试验(RCT)和8篇观察性研究,共纳入患者1 764例,其中持续输注1 037例,间断输注727例。持续输注与间断输注引起的肾毒性发生率无显著性差异(P>0.05)。结论万古霉素持续输注较间断输注不能有效降低肾毒性的发生率。Objective To compare the renal toxicity of vancomycin with continuous infusion vs intermittent infusion.Methods The databases of EMBASE,PUBMED,the Cochrane Register of Controlled Trials,CBM,CNKI and WanFang were searched.The Cochrane Revman5.2 software was used for Meta-analysis.Results Two RCTs and eight observational studies were included in the systematic literature search with total of 1 764 patients.1 037 patients received vancomycin with continuous infusion while 727 patients with intermittent infusion.The Meta-analysis indicated that there was no significant difference in renal toxicity between continuous infusion group and intermittent infusion group(P>0.05).Conclusion Vancomycin continuous infusion cannot effectively reduce the incidence of renal toxicity.

关 键 词：万古霉素 持续输注 间断输注 肾毒性 荟萃分析 

分 类 号：R969[医药卫生—药理学]