丹红注射液辅助西药对糖尿病合并脑梗死患者血管内皮功能的影响及疗效研究  

Effects of Danhong Injection on Vascular Endothelial Function in Patients with Diabetes Mellitus Complicated with Cerebral Infarction

作　　者：董丹[1] 李佳佳[2] 尚宜星 张晓晓[2] 杜星霖 王豫川[2] 

机构地区：[1]河南科技大学第一附属医院制剂室,河南洛阳471003 [2]河南科技大学第一附属医院门诊药房,河南洛阳471003 [3]河南科技大学第一附属医院住院药房,河南洛阳471003

出　　处：《中华中医药学刊》2018年第3期712-715,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：河南省教育厅科学技术研究重点项目(142182310065)

摘　　要：目的：观察丹红注射液辅助西药治疗糖尿病合并脑梗死临床疗效、安全性,及对患者血管内皮功能的影响,为临床糖尿病合并脑梗死治疗方案选择提供参考。方法：156例糖尿病合并脑梗死患者（均为恢复期腔隙性脑梗死）,随机分为A、B、C 3组,每组52例。3组患者均采用糖尿病常规治疗及脑梗死内科对症治疗,A组患者加用丹红注射治疗,B组患者加用依达拉奉治疗,C组患者加用丹红注射用和依达拉奉治疗,3组患者均连续治疗2周。比较3组患者治疗前、治疗后的血浆内皮素（endothelin,ET）、血浆一氧化氮（nitric oxide,NO）水平、神经功能缺损（NIHSS）评分、血糖控制效果（空腹血糖、非空腹血糖）、脑梗死临床总疗效率及治疗过程中的药物不良反应情况。结果：3组患者性别、年龄、入组前体质量、BMI指数、空腹血糖、非空腹血糖、梗死灶部位、梗死灶数量、梗死灶直径大小、糖尿病病程、脑梗死病程比较差异无统计学意义（P〉0.05）。3组患者治疗2周后,空腹血糖、非空腹血糖均得到有效控制,组间比较差异无统计学意义（P〉0.05）,ET、NIHSS评分均较治疗前明显降低,NO明显升高（P〈0.05）,治疗后组间比较,C组ET、NIHSS评分均低于A、B组,NO高于A、B组,差异有统计学意义（P〈0.05）,A、B组间比较差异无统计学意义（P〉0.05）。C组患者脑梗死临床总有效率明显高于A、B两组患者（P〈0.05）,A、B两组比较差异无统计学意义（P〉0.05）。3组患者治疗期间药物不良反应比较,C组高于A、B组,但组间比较差异均无统计学意义（P〉0.05）。所有患者经对症处理后均完成研究。结论：丹红注射液辅助西药依达拉奉治疗糖尿病合并脑梗死,可有效改善患者血管内皮功能,提高临床疗效,并不增加药物不良反应率,是适合糖尿病合并脑梗死患者（均为恢复期腔隙性脑梗死）的治疗方案。Objective： To observe the clinical curative effect of Danhong Injection and Western medicine in the treatment of diabetes mellitus complicated with cerebral infarction and safety,and effect on vascular endothelial function to provide a reference for the selection of clinical treatment of diabetes complicated with cerebral infarction. Methods： A total of 156 cases of diabetic patients with cerebral infarction（ all recovered lacunar infarction） were randomly divided into A,B,C three groups,each group 52 cases. Three groups patients were treated with diabetic cerebral infarction medicine routine treatment and symptomatic treatment. A group were treated with Danhong Injection treatment and B group were added edaravone treatment. C group were treated with Danhong injection and edaravone treatment group. Three patients were treated for 2 consecutive weeks. Before and after treatment,the three groups＇ cultured vascular endothelial cells（ endothelin,ET）,nitric oxide（ nitric oxide,NO） level,neural function defect score（ NIHSS）,the effect of blood glucose control（ non fasting blood glucose,fasting blood sugar） and adverse drug reactions of total clinical efficiency andtreatment of cerebral infarction were compared. Results： Three groups patients＇ gender,age,body weight before treatment,BMI index,fasting blood glucose,fasting blood glucose,non infarction,infarction,infarct size,the number of diabetes and cerebral infarction disease had no significant difference（ P 0. 05）. After 2 weeks of treatment,three groups＇ fasting blood glucose was controlled effectively and there was no significant among between groups（ P 0. 05）. ET and NIHSS scores were significantly lower than that before treatment and NO increased significantly（ P 0. 05）. After treatment,C group＇s ET and NIHSS scores were lower than those of the A and B groups and NO was higher than that of A and B group. The difference was statistically significant（ P 0. 05） and there was no significant difference between A group

关 键 词：糖尿病合并脑梗死 丹红注射液 血管内皮功能 临床疗效 药物不良反应 

分 类 号：R587.2[医药卫生—内分泌]