低频全身振动训练对正常大鼠脑结构无损伤作用  

Safety of Low Frequency Whole Body Vibration to the Brain Structure in Rats

作　　者：付慧[1] 黄丹[2] 王朴 金荣疆[1] 

机构地区：[1]成都中医药大学,四川成都610075 [2]四川大学,四川成都610075

出　　处：《中医药临床杂志》2018年第1期96-100,共5页Clinical Journal of Traditional Chinese Medicine

摘　　要：目的:探讨低频WBV训练对正常大鼠脑结构和脑内神经细胞的影响。方法:1-2月龄雄性SD大鼠(280-300g)随机分为正常组(n=6)和WBV训练组(n=6),WBV训练组大鼠接受WBV干预,频率15Hz,振幅5mm,30min,1次/d,干预7d。每天记录大鼠体重,干预期间密切观察大鼠的行为,观察脑结构的改变和神经细胞的表达情况。结果:WBV组大鼠体重在7d内的增长较正常组小,WBV刺激下无特殊异常行为学表现。H&E染色显示皮质区和海马区域除有少量增多的凋亡神经元外,其余结构无明显改变。免疫组化显示海马区星型胶质细胞排列欠整齐,数量无明显变化;皮质区星型胶质细胞数量和突起数量减少,血管附近较聚集,与正常组无明显区别。结论:低频短时间的WBV训练对正常大鼠脑结构及神经细胞的分布无明显副作用,但其长时间的刺激作用及对神经系统疾病的治疗效果还有待进一步探讨。Objective： To investigate the effects of low frequency WBV training on brain structure and neuronal cells in normal rats. Results： The body weight of rats in WBV group increased less than that of normal group in 7 days,and no abnormal behavior was observed in WBV rats. HE staining showed no significant changes in other structures except for a small number of apoptotic neurons in the cortex and hippocampus. Immunohistochemistry showed that astrocytes in the hippocampus were arranged in a regular pattern with no obvious change in number. The number of astrocytes and the number of neurites in the cortical area were decreased, and the vicinity of the blood vessels were more aggregated, showing no significant difference from the normal group. Conclusion： WBV training in low frequency and short time has no obvious side effects on the brain structure and distribution of nerve cells in normal rats. However, its long-term stimulating effect and therapeutic effect on nervous system diseases still need to be further explored.

关 键 词：全身振动训练 正常大鼠 脑结构 行为学 安全性 

分 类 号：R49[医药卫生—康复医学]