自拟降压方治疗顽固性高血压的临床疗效及对Hcy、AngⅡ的影响  

Clinical Curative Effect 0f Self-made Antihypertensive Prescription on Treatment of Refractory Hypertension and its Effect on Hcy and AngⅡ

作　　者：何志良[1] 高江宝 孙武[1] 陈冠姿 

机构地区：[1]广州市番禺区中医院,广东广州511400

出　　处：《云南中医中药杂志》2018年第2期33-35,共3页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

摘　　要：目的探讨自拟降压方治疗顽固性高血压的临床疗效。方法将64例顽固性高血压患者为研究对象,按随机数字表法分为观察组33例和对照组31例,对照组采用西医规范治疗,观察组在此基础上给予口服自拟降压方联合降压方足浴治疗,疗程3月。结果 2组患者的收缩压及舒张压均出现了下降,差异有统计学意义(P<0.05),但下降程度及血压达标率,观察组明显优于对照组,差异有统计学意义(P<0.05)。2组患者的AngⅡ平均较前下降,差异有统计学意义(P<0.05),但改善程度观察组优于对照组,差异有统计学意义(P<0.05);2组患者的Hcy平均较前下降,观察组治疗前后比较,差异有统计学意义(P<0.05);对照组治疗前后比较,差异无统计学意义(P>0.05)。2组患者的SAS、SDS、SPIEGEL评分均出现改善,差异有统计学意义(P<0.05),但改善程度,观察组明显优于对照组,差异有统计学意义(P<0.05)。结论自拟降压方能改善焦虑、抑郁情绪,降低Hcy、AngⅡ的水平,达到控制高血压,提高临床疗效。Objective： To study the clinical effect of self- made antihypertensive prescription on the treatment of refractory hypertension. Methods ： 64 patients were divided into an observation group （ n = 33 ） and a control group （ n = 31 ） according to random number ta- ble. The control group was given western medicine of standard treatment. The observation group, on the basis of western medicine of the control group, was given oral self - made antihypertensive decoction combined with foot bath treatment. The course was 3 months. Results ： The systolic and diastolic blood pressures of the two groups decreased and the difference was significant （ P 〈 0.05 ）, but the degree of decline and blood pressure compliance rate of the observation group were significantly higher than those of the control group （ P 〈 0.05 ）. The mean AngⅡ of the patients in the two groups was lower than before and the difference was statistically significant（ P 〈 0.05 ）, but the degree of improvement in the observation group was superior to that in the control group, with a significant difference （ P 〈 0.05 ）. The mean Hey of the two groups decreased than before. The comparison of pre - and - post treatment of the observation group showed the difference was statistically significant （P 〈 0. 05）, The comparison of pre - and - post treatment of the control group showed the difference was not statistically significant （P 〉 0.05）. The scores of SAS, SDS and SPIEGEL in the two groups improved, and the difference was statistically significant （ P 〈 0.05 ）, but the improvement in the observation group was better than that in the control group and the difference was statistically significant （ P 〈 0.05）. Conclusion： Self - made hypotension prescription can improve anxiety and depression, reduce the levels of Hey and AngⅡ and achieve the goal of controlling hypertension and improving clinical effectiveness.

关 键 词：疏肝熄风 顽固性高血压 焦虑 抑郁 

分 类 号：R544.1[医药卫生—心血管疾病]