轮状病毒肠炎患儿395例肝功能及心肌酶谱分析  

Analysis of liver function and myocardial enzyme level of 395 cases with infantile rotavirus enteritis

作　　者：吴倩[1] 吴起武 张海龙 杨文文[1] 莫壮斌 边晓锋 洪超畅 

机构地区：[1]海南省第二人民医院儿科,海南省五指山572299 [2]中山市广济医院儿科,广东省中山528427

出　　处：《中国基层医药》2018年第2期193-196,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 了解轮状病毒（RV）肠炎患儿肝脏、心肌损害发生率,为防治RV肠炎并发肝脏、心肌损害提供依据.方法 收集RV肠炎住院患儿395例的肝功能和心肌酶检验结果进行回顾性分析,并与同期体检健康儿童40例进行比较.结果 RV肠炎患儿丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、血清肌酸激酶（CK）、血清肌酸激酶同功酶（CK-MB）分别为（34.49±29.13）U/L、（52.44±24.10）U/L、（141.75±132.22）U/L、（48.69±32.53）U/L,均高于对照组的（16.00±3.24）U/L、（29.90±3.76）U/L、（101.82±64.56）U/L、（22.32±8.98）U/L（t=4.008、5.901、3.982、5.64,均P〈0.05）;RV肠炎患儿ALT、AST、CK、CK-MB异常发生率分别为19.49％、73.16％、12.15％、73.16％,均高于对照组的2.50％、20.00％、0.00％、0.00％,差异均有统计学意义（χ2=7.128、47.397、5.464、300.239,均P〈0.05）.RV肠炎患儿肝损害、心肌损害发生率分别为19.49％、73.16％.结论 RV肠炎患儿肝脏及心肌损害发生率高,对RV肠炎患儿应及时进行肝功能和心肌酶检查,治疗RV肠炎时,除抗病毒、纠正脱水等治疗外,要注意保护肝脏及营养心肌的治疗. Objective To detect the damage incidence rate of liver and myocardium in infantile rotavirus （RV） enteritis.And to provide the basis for prevention and cure of liver and myocardium damage in infantile RV enteritis.Methods The liver function and myocardial enzyme detection results of 395 patients with infantile RV enteritis were collected .These results were compared with those of 40 healthy kids from health examinations . Results The levels of alanine aminotransferase （ ALT ） , aspartate amino transferase （ AST ） , serum creatine kinase （CK） and serum creatine kinase isozyme（CK-MB） from infantile patients were （34.49 ±29.13）U/L,（52.44 ± 24.10）U/L,（141.75 ±132.22）U/L and （48.69 ±32.53）U/L,respectively,which were higher than those of the healthy control [（16.00 ±3.24）U/L,（29.90 ±3.76）U/L,（101.82 ±64.56）U/L and （22.32 ±8.98）U/L,t=4.008,5.901,3.982,5.64,all P〈0.05].The abnormal occurrence rates of ALT ,AST,CK and CK-MB in infantile patients were 19.49%,73.16%,12.15%,73.16%,respectively,which were higher than those in healthy controls （2.50%,20.00%,0.00%,0.00%）,the differences were statistically significant （χ2 =7.128,47.397,5.464, 300.239,all P〈0.05）.The incidence rates of liver and myocardium damage were 19.49%and 73.16%,respectively. Conclusion There are higher incidence rates of liver and myocardium damage in infantile RV enteritis .So for the infantile RV enteritis patients ,it is necessary to detect the liver function and myocardial enzyme level .The treatment for infantile RV enteritis should be included liver and myocardial protection except antivirus and correcting dehydration .

关 键 词：肠炎 轮状病毒感染 肝功能试验 心肌疾病 儿童 

分 类 号：R725.1[医药卫生—儿科]