川芎嗪辅助治疗糖尿病周围神经病变的疗效及对血清C反应蛋白水平的影响  

Effect of ligustrazine on diabetic peripheral neuropathy and its influence on the level of serum CRP

作　　者：王萍 

机构地区：[1]德州市市立医院内分泌科,山东省德州253012

出　　处：《中国基层医药》2018年第2期236-240,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探究川芎嗪辅助治疗糖尿病周围神经病变的疗效及对血清C反应蛋白（CRP）水平的影响.方法 选取糖尿病周围神经病变患者76例为研究对象,采用随机数字表法将患者分为两组各38例,对照组给予甲钴胺治疗,研究组在对照组基础上加用川芎嗪治疗.观察比较两组临床疗效、多伦多临床神经病变（TCSS）评分、血清CRP水平.结果 研究组治疗后显效20例（52.6％）,有效15例（39.5％）,无效3例（7.9％）,对照组显效13例（34.2％）,有效14例（36.8％）,无效11例（28.9％）.研究组临床疗效显著优于对照组（Z=-6.447,P〈0.05）;研究组治疗总有效率（92.1％）高于对照组（71.1％）,但差异无统计学意义（χ2=2.706,P〉0.05）.两组TCSS评分均较治疗前显著改善（均P〈0.05）;治疗后,研究组TCSS评分为（7.24±2.36）分,低于对照组的（9.08±2.94）分（t=3.009,P〈0.05）.两组血清CRP水平均较治疗前显著降低（均P〈0.05）;治疗后,研究组血清CRP水平为（2.82±0.36）mg/L,较对照组的（3.48±0.96）mg/L显著更低（t=3.968,P〈0.05）.结论 川芎嗪辅助治疗糖尿病周围神经病变可显著改善神经病变症状,降低血清CRP水平,临床疗效理想. Objective To investigate the effect of ligustrazine on diabetic peripheral neuropathy （ DPN） and its influence on the level of serum C reactive protein （CRP）.Methods 76 patients with DPN were selected as the subjects .According to the random number table method ,the patients were randomly divided into two groups ,38 cases in each group .The control group was given mecobalamin treatment .The study group was treated with ligustrazine on the basis of the control group .The clinical efficacy of the two groups was observed and compared with the Toronto clinical neurological lesion （ TCSS） score and serum CRP level .Results The study group was markedly effective in 20 cases（52.6%）,effective in 15 cases（39.5%）,ineffective in 3 cases（7.9%）.In the control group,the markedly effective in 13 cases （34.2%）,effective in 14 cases（36.8%）,invalid in 11 cases（28.9%）.The clinical efficacy of the study group was significantly better than that of the control group （Z=-6.447,P〈0.05）.The total effective rate of the study group（92.1%） was higher than 71.1%of the control group,the difference between the two groups was not statistically significant（χ2 =2.706,P〉0.05）.The TCSS scores of the two groups were significantly higher than before treatment（all P〈0.05）.After treatment,the TCSS score of the study group [（7.24 ±2.36）points]was significantly lower than（9.08 ±2.94）points of the control group（t=3.009,P〈0.05）.The serum CRP levels of the two groups were significantly lower than before treatment （all P〈0.05）,and the serum CRP level of the study group [（2.82 ±0.36）mg/L]was significantly lower than that of the control group [（3.48 ±0.96）mg/L]（t=3.968,P〈0.05）.Conclusion Ligustrazine in the treatment of patients with DPN can significantly improve the degree of neuropathy and reduce the level of serum CRP ,so the clinical efficacy is ideal .

关 键 词：川芎嗪 糖尿病神经病变 疗效比较研究 C反应蛋白质 

分 类 号：R587.2[医药卫生—内分泌]