硫辛酸对2型糖尿病下肢血管病变患者血清8异前列腺素F2α水平的影响  

Influence of lipoic acid on serum 8-iso-prostaglandin F2α level in type 2 diabetic patients with lower venous extremity

作　　者：邱轩[1] 孙建璞[2] 蔡思嘉 徐晓蒙[1] 刘宽芝[1] 

机构地区：[1]河北医科大学第三医院内分泌一科,河北石家庄050051 [2]河北省老年病医院内分泌科,河北石家庄050000

出　　处：《临床荟萃》2018年第3期232-235,共4页Clinical Focus

基　　金：2017年政府资助省级临床医学优秀人才项目

摘　　要：目的观察硫辛酸对2型糖尿病(T2DM)下肢血管病变患者血清8异前列腺素F2α(8-iso-PGF2α)水平的影响。方法选择T2DM患者288例,根据踝肱比(ABI)分为单纯T2DM组191例和下肢血管病变组97例,下肢血管病变组又分为常规治疗组和硫辛酸组。硫辛酸治疗剂量0.6g/d,疗程2周。并设正常对照组100例。检测治疗前后血清8-iso-PGF2α水平,记录治疗前后无痛行走距离和最大行走距离。结果单纯T2DM组血清8-iso-PGF2α水平明显高于正常对照组(P<0.05);下肢血管病变组血清8-iso-PGF2α水平高于单纯T2DM组(P<0.05)。经过2周的治疗,常规治疗组和硫辛酸组血清8-iso-PGF2α水平均有所下降,硫辛酸组降低较为明显(P<0.05);两组无痛行走距离及最大行走距离均有所增加(P<0.05),硫辛酸组增加较为明显(P<0.05)。结论血清8-iso-PGF2α水平与T2DM下肢血管病变程度有关,硫辛酸可以降低T2DM下肢血管病变患者的血清8-iso-PGF2α水平,并改善临床症状。Objective To investigate the influence of lipoic acid on the serum 8-iso-prostaglandin F2α(8-isoPGF2α)level in type 2 diabetic patients with lower venous extremity.Methods This study recruited`288 patients with type 2 diabetes,including 191 patients with only type 2 diabetes(T2DM group)and 97 type 2 diabetic patients with peripheral artery disease(LVED group)in accordance with ankle-brachial index(ABI).The LVED group was divided into two groups:conventional therapy group received conventional therapy and the other lipoic acid group was given lipoic acid 0.6 g a day for two weeks on the basis of conventional therapy.An age-and sex-matched group of 100 healthy subjects were also recruited.The serum 8-iso-PGF2αlevel was measured.The painless walking distance and the maximum walking distance before and after treatment were recorded.Results The serum 8-iso-PGF2αlevel in T2DM group was significantly higher than that in control group(P <0.05).The serum 8-iso-PGF2αlevel in LVED group was significantly higher than that in T2DM group(P <0.05).The serum 8-iso-PGF2αlevel was positively correlated with the severity of LVED.After two weeks treatment,the serum 8-iso-PGF2αlevel in conventional therapy group and lipoic acid group both decreased,and that in lipoic acid group was significantly lower(P <0.05).In addition,the painless walking distance and the maximum walking distance in conventional therapy group and lipoic acid group significantly increased(P <0.05),and those in lipoic acid group were significantly longer(P <0.05).Conclusion The serum 8-iso-PGF2αlevel is correlated with the severity of LVED.Lipoic acid could decrease the serum 8-iso-PGF2αlevel and improve the clinical symptoms in type 2 diabetic patients with LVED.

关 键 词：糖尿病 2型 糖尿病血管病变 异前列腺素 硫辛酸 

分 类 号：R587.1[医药卫生—内分泌]