重组干扰素α-1b联合苦参素治疗慢性乙型肝炎的临床观察  

Clinical observation of interferon α-1b combined with oxymatrine in the treatment of chronic hepatitis B

作　　者：张经良 顾晶晶 王天东 

机构地区：[1]山东省淄博市第四人民医院药剂科,淄博255067 [2]山东省淄博市第四人民医院传染一科,淄博255067

出　　处：《中国临床药理学与治疗学》2002年第4期344-346,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 :探讨重组干扰素α 1b(干扰素 )联合苦参素治疗慢性乙型肝炎的疗效及不良反应。方法 :选择慢性乙型肝炎患者 87例 ,随机分成干扰素 +苦参素组 45例 ,给予干扰素治疗 ,第 1～ 4wk 3 0 μg·d-1,im ,以后改为隔日 3 0 μg,im ,疗程为 3mon,同时加苦参素注射液 60 0mg·d-1,im ,疗程为 3mon。干扰素组 42例 ,单用干扰素治疗 ,剂量、疗程与治疗组相同 ,在疗程结束时 ,观察两组患者肝功能、乙型肝炎病毒血清学 (HBVM)标志的变化。结果 :两组患者血清谷丙转氨酶 (ALT)的复常率分别为 88.9%和60 % ,组间差异有显著性 (P <0 .0 5 ) ;HBeAg阴转率分别为 5 5 .6%和 3 5 .7% ,HBV DNA阴转率分别为5 7.8%和 42 .9% ,治疗组的疗效明显优于对照组 (P<0 .0 5 ) ,未见明显不良反应。结论 :干扰素联合苦参素具有改善肝功能和抑制乙肝病毒复制等功效 ,两者联合应用可作为慢性乙型肝炎的一种治疗方案。AIM: To observe the efficacy and side effects of interferon α 1b (interferon) combined with oxymatrine in the treatment of chronic hepatitis B. METHODS: 87 patients were randomly divided into two groups: 45 patients in treatment group were given interferon 30 μg·d -1 (im) for 4 wk, then 30 μg·d -1 (im, qod) combined with oxymatrine 600 mg·d -1 (im) for 3 mon; 42 patients in control group were given the same dose of interferon as above only. After completion of therapy, liver function and markers of HBVM were compared between the two groups. RESULTS: The rates of ALT decreased to normal range in treatment group and control group were 88.9 % and 60%, respectively (P< 0.05 ). The rate of HBeAg turned to negative was 55.6 % in treatment group and 35.7 % in control group; the rate of HBV DNA turned to negative was 57.8 % in treatment group and 42.9 % in control group (P< 0.05 ). Side effects were not found in the two groups. CONCLUSION: Interferon α 1b combined with oxymatrine can improve liver function and inhibit HBV replication. It suggests that the combination may be a scheme in the treatment of chronic hepatitis B.rnedtonegativewas 5 7.8%intreatmentgroupand42 .9%incontrolgroup (P <0 .0 5 ) .Sideeffectswerenotfoundinthetwogroups.CONCLUSION :Interferonα 1bcombinedwitho

关 键 词：重组干扰素Α-1B 苦参素 治疗 慢性乙型肝炎 临床观察 

分 类 号：R512.62[医药卫生—内科学]