耳复康口服液对小鼠微循环障碍的影响  

Effect of Erfukang Oral Liquid on Microcirculation Disturbance in Mice

作　　者：管志江[1] 郝少君[1] 刘晓斌[1] 范莉莉[1] 李文俊[1] 张正臣[1] 

机构地区：[1]解放军第371中心医院,河南新乡453000

出　　处：《中国药师》2018年第3期402-404,共3页China Pharmacist

基　　金：河南省科技重点科技攻关项目(编号:132102310408);河南新乡市重点科技攻关项目(编号:ZG14014)

摘　　要：目的:观察耳复康口服液对肾上腺素致急性血瘀症小鼠微循环障碍的影响。方法:将小鼠随机分为模型组,脑得生片组(1.35 g·kg^(-1)),高(30 ml·kg^(-1))、中(15 ml·kg^(-1))、低(7.5 ml·kg^(-1))剂量耳复康口服液组,用微循环仪观察正常小鼠给药1 h后毛细血管开放数。尾静脉注射肾上腺素造成耳廓微循环障碍,观察造模后2 min小鼠的毛细血管开放数及血流情况。结果:和模型组相比,高、中、低剂量耳复康口服液对正常小鼠耳廓毛细血管开放数无明显影响(P>0.05);与模型组相比,高、中剂量耳复康口服液可显著改善肾上腺素致小鼠耳壳微循环障碍模型微循环血流情况(P<0.05或P<0.01),可明显对抗肾上腺素所致小鼠耳壳微循环障碍模型毛细血管网开放数的减少(P<0.05)。结论:耳复康口服液有改善微循环障碍的作用。Objective： To observe the effect of Erfukang oral liquid on microcirculation disturbance in mice with acute blood stasis caused by adrenaline. Methods： The mice were randomly divided into the blank group,Naodesheng group（ 1. 35 g·kg^-1）,Erfukang oral liquid group respectively at high（ 30 ml·kg^-1）,medium（ 15 ml·kg^-1） and low（ 7. 5 ml·kg^-1） dose,and a microcirculation apparatus was used to observe the number of capillary opening in the normal mice at one hour after the administration. The microcirculation disturbance of auricle was induced by the injection of epinephrine into caudal vein. The number of capillary opening and blood flow in 2 min in the mice were observed. Results： Compared with the blank group,Ergukang oral liquid at high,medium and low dose showed effect on the number of opening capillaries without statistical significance（ P〈0. 05）; compared with the model group,Erfukang oral liquid at high and medium dose could significantly improve the microcirculation induced by epinephrine（ P〈0. 05 or P〈0. 01）,and significantly confront the decreased number of capillary network opening induced by adrenaline（ P〈0. 05）. Conclusion：Erfukang oral liquid can improve microcirculation disturbance.

关 键 词：耳复康口服液 肾上腺素 微循环障碍 小鼠 

分 类 号：R285.5[医药卫生—中药学]