火车司机抑郁症状评分与载脂蛋白A1和B的关系  

The relationship between depressive symptom scores and apolipoprotein A1 and B of train drivers

作　　者：周文慧 吴辉 谷桂珍 余善法 

机构地区：[1]河南省职业病防治研究院,河南郑州450052

出　　处：《工业卫生与职业病》2018年第1期1-6,共6页Industrial Health and Occupational Diseases

基　　金：河南省医学科技攻关计划重大项目(201001009);河南省卫生科技创新型人才工程科技领军人才基金(3022)

摘　　要：目的探讨动车或高铁司机抑郁症状评分与载脂蛋白A1和B的关系。方法采用整群抽样的方法,于2012年3月对某铁路局机务段60名动车或高铁司机进行横断面调查和血清载脂蛋白A1和B的实验室检测;调查内容包括抑郁症状、个体统计学特征因素、职业紧张因素、紧张反应和紧张缓解因素;采用流行病学调查用抑郁自评量表来测评调查对象的抑郁症状,使用修订的付出-回报失衡模式(ERI)问卷和职业紧张测量工具对职业紧张因素、紧张反应和紧张缓解因素进行测评;血清载脂蛋白A1和B的浓度采用免疫比浊法进行测定;采用分层多元逐步回归法分4个模式分析在年龄、工龄、职业紧张因素、紧张反应和紧张缓解因素的影响下抑郁症状和血清载脂蛋白A1和B的关系。结果调查对象血清载脂蛋白A1的平均浓度为(1.19±0.16)g/L,浓度范围为(0.80~1.57)g/L;血清载脂蛋白B的平均浓度为(0.81±0.34)g/L,浓度范围为(0.40~2.80)g/L。Spearman等级相关分析结果显示,血清中载脂蛋白A1的浓度与年龄、工龄、抑郁症状等调查变量均没有关联性(P>0.05);血清中载脂蛋白B的浓度倒数与年龄(r=-0.208,P=0.026)和抑郁症状评分(r=0.279,P=0.008)相关,与其他变量没有关联性(P>0.05)。以载脂蛋白A1为应变量的分层多元逐步回归分析设计了的4个模式的结果均显示,抑郁症状评分未进入回归方程,但组内冲突评分进入了2、3和4模式(变化R^2均为0.087,P值均为0.035);以载脂蛋白B倒数为应变量的分层多元逐步回归分析设计的4个模式中,模式1中结果显示:调整了年龄和工龄后,抑郁症状评分进入了回归方程(变化R^2=0.095,P=0.026);模式2结果显示:调整了年龄、工龄、工作环境、外在付出、回报、工作责任和工作冲突后,抑郁症状评分和内在付出评分进入了回归方程(变化R^2分别为0.065和0.092,P<0.01);模式3结果显示:调整了年龄、工龄、工作环境�Objective To explore the relationship between depressive symptom scores and apolipoprotein A1 and B of EMU or high-speed rail drivers.Methods A cross-sectional study was conducted in 60 EMU or high-speed rail drivers from a Railway Bureau depot in Henan Province in China;The Questionnaire included depressive symptom,general factors,occupational stress factors,psychological factors and mitigating factors.Depressive symptom was asessed by depressive symptom rating scale,other psychosocial work factors were measured by using the effort-reward imbalance model questionnaires and occupational stress measurement scale.Concentration of apolipoprotein A1 and B in the plasma were detected by immunonephelometry.Stepwise regression analysis was applied to analyze the relationship between depressive symptom scores and apolipoprotein A1 or B of EMU or high-speed rail drivers.Results The concentration of apolipoprotein A1 and B of the survey population was（1.19±0.16）g/L and（0.81±0.34）g/L respectively.Correlation analysis showed that concentration of apolipoprotein A1 in the plasma had no correlation with all variables（P〈0.05）.The reciprocal of concentration of apolipoprotein B in the plasma and age（r=-0.208,P =0.026）and depressive symptom scores（r=0.279,P =0.008）were correlated,no correlation with other variables（P〈0.05）;Stepwise regression analysis was designed for four modes.When apolipoprotein A1 was used as the dependent variable,all modes indicated that depressive symptom did not enter the regression equation.When apolipoprotein B was used as the dependent variable,all modes showed that depressive symptom was predictors of apolipoprotein B after adjusting for age and length of service,occupational stress factors,psychological factors and mitigating factors（R^2=0.095）.Conclusions The depressive symptom score of EMU or high-speed rail drivers was not associated with serum apolipoprotein A1,but was related to the expression of serum apolipoprotein B,and the concentration of apolipoprotein B i

关 键 词：职业卫生 动车或高铁司机 抑郁症状 职业紧张 载脂蛋白A1和B 

分 类 号：R135[医药卫生—劳动卫生] R395.6[医药卫生—公共卫生与预防医学]