子痫前期与妊娠合并慢性肾脏病孕妇血清免疫球蛋白、β2微球蛋白和转铁蛋白水平的比较  

Analysis of the difference of serum immunoglobulins, β2-microglobulin and transferrin in pre-eclampsia and pregnancies complicated with chronic kidney disease

作　　者：庄旭[1] 陆漪婷 陈云燕[1] 林建华[1] 

机构地区：[1]上海交通大学医学院附属仁济医院妇产科,200127 [2]上海交通大学医学院附属仁济医院检验科,200127

出　　处：《中华妇产科杂志》2018年第2期77-81,共5页Chinese Journal of Obstetrics and Gynecology

基　　金：国家科技支撑计划（2014BAI05B05）

摘　　要：目的比较子痫前期（PE）与妊娠合并慢性肾脏病孕妇的血清IgA、IgG、IgM及β2微球蛋白、转铁蛋白水平的差异。方法收集2017年2月至7月于上海交通大学医学院附属仁济医院住院的孕妇共115例，其中PE孕妇（PE组）46例（40.0%），妊娠合并慢性肾脏病孕妇（肾脏病组）36例（31.3%），正常孕妇（对照组）33例（28.7%），分别检测并比较3组孕妇血清中免疫球蛋白（包括IgA、IgG、IgM）及β2微球蛋白、转铁蛋白的水平，将血压、24 h尿蛋白定量及分娩孕周与血清免疫球蛋白、β2微球蛋白、转铁蛋白水平进行相关性分析。结果（1）3组孕妇一般情况的比较：3组孕妇的年龄、孕次、产次分别比较，差异均无统计学意义（P均〉0.05）；3组孕妇的舒张压、收缩压及分娩孕周分别比较，差异均有统计学意义（P均〈0.01）。PE组与肾脏病组孕妇的24 h尿蛋白定量比较，差异无统计学意义（Z=-0.187，P=0.852）。（2）3组孕妇的血清免疫球蛋白、β2微球蛋白、转铁蛋白水平的比较：肾脏病组孕妇的血清IgA水平明显高于PE组及对照组孕妇[分别为（2.4±0.9）、（1.8±0.9）、（1.6±0.6）g/L；F=9.959，P〈0.01]。3组孕妇的血清IgG及IgM水平分别比较，差异均无统计学意义（P均〉0.05）。肾脏病组孕妇的血清β2微球蛋白水平明显高于PE组及对照组孕妇[分别为（4.0±2.6）、（2.7±0.7）、（2.0±0.5）mg/L；F=15.892，P〈0.01]。肾脏病组孕妇的血清转铁蛋白水平明显低于PE组及对照组孕妇[分别为（3.0±0.8）、（3.7±1.1）、（3.6±0.6）g/L；F=6.284，P〈0.01]。（3）PE组孕妇的血压、24 h尿蛋白定量及分娩孕周与其血清蛋白水平的相关性：PE组孕妇的血压与血清IgA、β2微球蛋白及转铁蛋白水平均无相关性（P均〉0.05）；24 h尿蛋白定量与β2微球蛋白的水平呈明显正相关（r=0.557，P〈0.01），与转铁蛋白水平呈明显负Objective To observe and analyze the difference of serum immunoglobulin IgA, IgG, IgM, β2-microglobulin and transferrin in pre-eclampsia （PE） and pregnancies complicated with chronic kidney disease.Methods Totally 46（40.0%） pregnancies with PE （PE group）, 36（31.3%） pregnancies with chronic kidney disease （chronic kidney disease group） and 33（28.7%） normal pregnancies with normal blood pressure and proteinuria without any complication （control group） delivered in Renji Hospital were recruicted in this study from February 2017 to July 2017. Serum IgA, IgG, IgM, β2-microglobulin and transferrin levels were detected. Correlation tests were conducted between these indicators and blood pressure, 24 hours proteinuria value and delivery weeks.Results （1） Comparison of general situation of pregnancies in the 3 groups： there were no significant difference in the age and child bearing history between the 3 groups （all P〉0.05）, while there was a significant difference in the blood pressure and deliver week （all P〈0.01）. There was no significant difference in 24 hours proteinuria values between PE group and chronic kidney disease group （Z=-0.187, P=0.852）. （2） Comparison of serum immunoglobulin, β2-microglobulin and transferrin levels in pregnant women with three groups： serum IgA level in chronic kidney disease group was significantly higher than those in PE and control groups [（2.4±0.9） vs （1.8±0.9） vs （1.6±0.6） g/L; F=9.959, P〈0.01]. The serum IgG and IgM values had no significant difference between the 3 groups （all P〉0.05）. Serum β2-microglobulin in chronic kidney disease group was significantly higher than those in PE and control groups [（4.0±2.6） vs （2.7±0.7） vs （2.0±0.5） mg/L; F=15.892, P〈0.01]. Serum transferrin in chronic kidney disease group was significantly lower than those in PE and control groups [（3.0±0.8） vs （3.7±1.1） vs （3.6±0.6） g/L; F=6.284, P〈0.01]. （3） The correlation between serum imm

关 键 词：先兆子痫 妊娠并发症 肾功能不全 慢性 免疫球蛋白类 Β2微球蛋白 转铁蛋白 

分 类 号：R714.244[医药卫生—妇产科学] R714.258[医药卫生—临床医学]