前列腺素E_2辅助球囊应用对足月阴道分娩产妇促宫颈成熟、产程及引产效果的影响  

Effects of prostaglandin E_2 assisted balloon application on vaginal delivery,cervical ripening and induction of labor in term vaginal delivery

作　　者：赵文斌[1] 王学平 陈香军 

机构地区：[1]杭州师范大学附属医院妇产科

出　　处：《中国临床药理学与治疗学》2018年第2期189-193,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：浙江省医药卫生科技计划项目(2015KYB378)

摘　　要：目的:研究前列腺素E_2辅助球囊对足月阴道分娩产妇的产程、促宫颈成熟以及引产效果的影响。方法:选取2016年3月至2017年3月在我院接受生产的足月产妇230例作为研究对象。将230例足月产妇用随机数表法分为观察组和对照组,每组各115例。两组产妇均进行胎心监测,对照组产妇给予美国库克COOK子宫颈扩张球囊,观察组产妇给予地诺前列酮栓辅助COOK子宫颈扩张球囊,并于放置COOK子宫颈扩张球囊后严密观察宫缩、胎心状况。观察阴道分娩产妇的产程、促宫颈成熟以及引产效果。结果:两组产妇在年龄、孕龄、初产妇人数、孕龄<37周人数以及Bishop评分等方面差异无统计学意义(P>0.05)。观察组产妇的引产成功率、Bishop评分和Bishop评分增长量分别为79.13%、(8.57±1.20)分和(5.87±1.41)分,对照组分别为64.35%、(7.03±0.68)分和(4.35±1.10)分,观察组高于对照组;观察组产妇的分娩时间、产后出血量、产程、第一产程和第二产程分别为(16.92±4.17)h、(203.40±30.78)mL、(6.38±1.77)h、(6.19±1.40)h和(24.37±5.61)min,对照组分别为(20.45±3.75)h、(234.94±42.04)mL、(7.93±1.77)h、(7.08±1.33)h和(34.63±8.18)min,观察组低于对照组,差异有统计学意义(P<0.05)。两组产妇的第三产程比较差异无统计学意义(P>0.05)。两组新生儿的Apgar评分、新生儿窒息和新生儿体质量比较差异无统计学意义(P>0.05)。观察组产妇宫颈成熟有效率为96.52%,高于对照组的82.61%,差异有统计学意义(P<0.05)。结论:前列腺素E_2辅助球囊可以缩短足月阴道分娩产妇的宫颈成熟时间,尽早地促进宫颈成熟,缩短分娩时间,提高引产成功率,且对新生儿情况无影响,值得在临床推广应用。AIM： To study the effects of prostaglandin E_2 assisted balloon on the vaginal delivery,cervical ripening and induction of labor in women undergoing full term vaginal delivery. METHODS：Two hundred and thirty cases of full-term mothers who were produced in our hospital from March 2015 to March 2017 were selected as subjects. Two hundred and thirty cases of full-term maternal random number table method were divided into observation group and control group,115 cases in each. Two groups of maternal were fetal heart rate monitoring.Pregnant women of observation group were given dinoprostone suppositories COOK cervical dilatation balloon,while pregnant women of the control group were given COOK cervical dilatation balloon,and placed COOK cervix after balloon. The shrink and fetal heart condition were closely monitored. Labor process,cervical ripening and induction of labor in pregnant women with vaginal delivery were observed. RESULTS： There was no significant difference between the two groups in age,gestational age,primipara number,gestational age,number of gestational age below 37 weeks and Bishop score（ P 0. 05）. The observation group ＇s success rate of induced labor,Bishop score and Bishop score growth were 79. 13%,（ 8. 57 ± 1. 20） score and（ 5. 87 ±1. 41） score,respectively,the control group were64. 35%,（ 7. 03 ± 0. 68） score and（ 4. 35 ± 1. 10）score,respectively,the observation group was higher than the control group. The observation group＇s labor time,postpartum hemorrhage,labor,first stage and second stage of labor were（ 16. 92 ± 4. 17） h,（ 203. 40 ± 30. 78） mL,（ 6. 38 ± 1. 77） h,（ 6. 19± 1. 40） h and（ 24. 37 ± 5. 61） min,respectively,the control group were（ 20. 45 ± 3. 75） h,（ 234. 94± 42. 04） mL,（ 7. 93 ± 1. 77） h,（ 7. 08 ± 1. 33）h and（ 34. 63 ± 8. 18） min,respectively; the observation group was lower than the control group,the difference was statistically significant（ P 0. 05）.There was no significant difference in the th

关 键 词：COOK球囊 前列腺素E_2 促宫颈成熟 引产 

分 类 号：R714.2[医药卫生—妇产科学]