全身麻醉药物遗传药理学研究进展  

Research progress of general anesthesia in the pharmacogenetics

作　　者：谢商宸 李玮[1,2] 廖萍[1,2] 贺毅憬[1,2] Howard L.Mcleod[1,2] 

机构地区：[1]中南大学湘雅医院临床药理研究所,湖南长沙410008 [2]中南大学临床药理研究所,遗传药理学湖南省重点实验室,湖南长沙410078

出　　处：《中国临床药理学与治疗学》2018年第2期217-222,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(81403022,81673517,81773821)

摘　　要：全身麻醉是指由多种全身麻醉药物引起的一系列无意识、记忆缺失、痛觉缺失、运动不能等状态。随着遗传药理学及药物基因组学的发展,全身麻醉中各类药物与自身遗传因素的关系越来越受到关注。本文对全身麻醉中常用的镇痛药、镇静催眠药、肌松药及止吐药的遗传药理学研究进行综述,归纳近年来的研究进展。General anesthesia is a state of unconsciousness,amnesia,analgesia and akinesia induced by drugs used in general anesthesia. Along with the development of pharmacogenetics and pharmacogenomics, pharmacogenetic studies of these drugs have been carried out continuously. This review summarizes the pharmacogenetics of commonly used general anesthesia drugs like analgesics,sedative-hypnotics, neuromuscular blockers and antiemetics in recent years.

关 键 词：全身麻醉 遗传药理学 药物基因组学 

分 类 号：R968[医药卫生—药理学]