妊娠期肝内胆汁淤积症孕妇凝血功能的变化及临床意义  

Changes of Coagulation Function in Pregnant Women with Intrahepatic Cholestasis of Pregnancy and Its Clinical Significance

作　　者：杨勇 蔡世川[2] 辛琴 

机构地区：[1]大连市妇幼保健院检验科,辽宁大连116023 [2]大连市儿童医院检验科,辽宁大连116012 [3]大连市妇幼保健院产科四病房,辽宁大连116023

出　　处：《中国医药指南》2018年第3期10-11,共2页Guide of China Medicine

摘　　要：目的探讨妊娠期肝内胆汁淤积症孕妇凝血功能的变化及临床意义。方法选取2015年12月至2016年12月在大连市妇幼保健院进行治疗的60例妊娠期肝内胆汁淤积症孕妇为研究组,60正常健康的妊娠孕妇,为健康对照组,研究两组患者的凝血功能具体为测凝血酶原时间(PT)、活化部分的凝血活酶时间(APTT)、凝血酶时间(TT)及纤维蛋白原(FIB)水平。结果研究组PT和FIB均高于健康对照组,差异有统计学意义(P<0.05)。结论妊娠期肝内胆汁淤积症孕妇其凝血功能会发生异常,通过检测凝血功能可以检测出妊娠期肝内胆汁淤积有助于临床诊断,希望在临床推广。Objective To study the disease of intrahepatic cholestasis during pregnancy pregnant women blood coagulation function of the change and clinical significance. Methods Selecting in December 2015 to December 2016 in dalian city maternal and child health care treatment of 60 cases of intrahepatic cholestasis during pregnancy pregnant women for the team and 60 normal, healthy pregnancy pregnant women, as the healthy control group, the two groups of blood coagulation function in patients with specific for measuring prothrombin time（PT）, activated partial clotting enzyme live time（APTT）, thrombin time（TT） and fibrinogen（FIB） level. Results The team of PT and Fib were higher than healthy control group, the difference was statistically significant（P〈0.05）. Conclusion The disease of intrahepatic cholestasis during pregnancy pregnant women blood coagulation function abnormal happens, by detecting blood coagulation function can detect intrahepatic cholestasis during pregnancy is helpful to clinical diagnosis, hope in clinical promotion.

关 键 词：妊娠期肝内胆汁淤积症 孕妇 凝血功能 

分 类 号：R714.25[医药卫生—妇产科学]