白杨素的结构修饰及其衍生物的生物活性研究进展  

Progress in Structure Modifications and Biological Activities of Chrysin Derivatives

作　　者：王京[1] 王杨[1] 杨杰[1] 张磊[1] 

机构地区：[1]遵义医学院药学院

出　　处：《化学试剂》2018年第3期225-230,共6页Chemical Reagents

基　　金：贵州省科技厅资助项目(黔科合LH字[2014]7557号,黔科合LH字[2014]7565号,黔科合基础[2017]1219);遵义医学院扶持学科(药物化学)建设项目

摘　　要：白杨素是一种分离自紫蒇科植物木蝴蝶的黄酮类天然产物，具有广泛的生物活性，如抗肿瘤、降糖、抗菌、杀虫、抗炎和抗氧化等。白杨素的重要药理活性引起了国内外研究人员的广泛关注，但其存在水溶性差、生物利用度低以及体内容易被糖基化代谢失活等不足。主要综述近年来白杨素结构修饰及其衍生物的活性研究进展，包括抗肿瘤、降糖、抗菌以及其他生物活性，以期有益于白杨素的进一步研究。Chrysin is a flavonoid extracted from Oroxylumindicum （L.）Vent, and it showed extensive biological achvltles, such as antitumor, hypoglycemic, antibacterial, insecticidal, anti-inflammatory and antioxidant, etc.So those important pharmacological ac- tivities caused the attention of researchers.However,some works also indicate that there are several disadvantages for chrysin,in- cluding poor soluble,poor bioavailability and glycosylation metabolic.Therefore,in order to improve the solubility of chrysin and enhance metabolic stability, a lot of the structure modification works have been made.Many derivatives of chrysin with various bio- logical activities have been obtained in recent years.This work will review the advance in the progress of structure modification of chrysin and biological activities of chrysin derivatives, mainly including anti-tumor, hypoglycemie, antibacterial and other biological activities for the further study of chrysin.

关 键 词：白杨素 结构修饰 衍生物 生物活性 

分 类 号：R284[医药卫生—中药学]