磺酸功能化壳聚糖催化合成氧杂蒽二酮衍生物  

Synthesis of 1,8-Dioxo-octahydroxanthene Derivatives Catalyzed by Sulfonic Acid Functionalized Chitosa

作　　者：王英磊[1] 刘学国[1] 杜朝军[1] 张莉[1] 

机构地区：[1]南阳理工学院生物与化学工程学院

出　　处：《化学试剂》2018年第3期295-298,304,共5页Chemical Reagents

基　　金：河南省高等学校重点科研资助项目(17B150-007)

摘　　要：壳聚糖是自然界中储量仅次于纤维素的生物质资源，具有价廉、无毒、可生物降解等优点。由于其分子中含有氨基和羟基等活性位点，易于通过简单的化学修饰来制备环境友好型催化剂。采用壳聚糖与氯磺酸的磺化反应，制备了磺酸功能化壳聚糖的固体酸性催化剂，在无溶剂条件下催化芳香醛和5，5-二甲基-1，3-环己二酮（或1，3-环己二酮）反应合成了一系列氧杂葸二酮衍生物，产率达84％～96％。该方法对环境友好、操作简单，且催化剂易于分离和回收使用，符合绿色化学的要求。Chitosan is the second most abundant biomass resource in nature next to cellulose,which has the advantages of low price,nontoxic and biodegradable.Chitosan is easy to prepare environmentally and friendly catalyst through simple chemical modi- fication,due to active sites of amino and hydroxyl groups.The solid acid of sulfonic acid functionalized chitosan was prepared by the sulfonation reaction of ehitosan and chloro sulfonic acid,which was applied as an efficient catalyst for the synthesis of a series of 1,8-dioxo-octahydroxanthene derivatives through the condensation of aromatic aldehyde and 5,5-dimethyl-1,3-cyclohexanedi- one （or 1,3-cyclohexanedione） under solvent-free conditions in yields of 84%- 96%.This method is friendly to environment, sim- ple manipulation, and the catalyst is easy to separate and reuse ,which meets the requirement of green chemistry.

关 键 词：磺酸功能化壳聚糖 氧杂葸二酮 无溶剂 重复使用 

分 类 号：O626.41[理学—有机化学]