益肾养阴通络方治疗气阴两虚型2型糖尿病肾病Ⅲ期临床观察  

Clinical Observation of Yishen Yangyin Tongluo Prescription for Type 2 Diabetes Nephropathy of Qi-yin Deficiency Type at Stage Ⅲ

作　　者：文辉[1] 易桂生[1] 胡小慧 

机构地区：[1]桂林医学院附属医院,广西桂林541001

出　　处：《新中医》2018年第2期32-35,共4页New Chinese Medicine

基　　金：广西医药卫生自筹经费计划课题(Z2015401)

摘　　要：目的:观察益肾养阴通络方治疗气阴两虚型2型糖尿病肾病Ⅲ期患者的临床疗效。方法:将80例门诊及住院患者随机分为2组各40例。对照组予西医降糖、降压治疗;治疗组在对照组治疗方案的基础上予益肾养阴通络方加减治疗。2组均治疗12周为1疗程,治疗1疗程观察疗效,观察2组治疗后临床症状、尿蛋白排泄率(UACR)、糖化血红蛋白(HbA1c)、24 h微量白蛋白(TP/24 h)、C-反应蛋白(CRP)、肾功能变化情况。结果:2组临床疗效比较,总有效率治疗组72.5%,对照组35.0%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分比较,差异有统计学意义(P<0.05)。治疗后,治疗组TP/24 h、UACR、肌酐(Cr)、CRP分别与治疗前比较,差异均有统计学意义(P<0.05);2组间TP/24 h、UACR、Cr、CRP比较,差异均有统计学意义(P<0.05)。2组HbA1c治疗前后及治疗后组间比较,差异均无统计学意义(P>0.05)。结论:益肾养阴通络方能有效减少气阴两虚型2型糖尿病肾病Ⅲ期患者的尿蛋白,改善患者的临床症状。Objective：To observe the clinical effect of Yishen Yangyin Tongluo prescription for type 2 diabetes nephropathy of Qi-yin deficiency type at stage III. Methods：Divided 80 cases of inpatients and outpatients into the control group and the treatment group randomly,40 cases in each group. Both groups received western medicine for antihypertation and lowering blood glucose,while the treatment group additionally received modified Yishen Yangyin Tongluo prescription,12 weeks as one course. After both groups received one course for treatment,observed changes of clinical symptoms,urinary albumin excretion rate（UAER）,glycosylated hemoglobin（HbA1 c）,C reactive protein（CRP）,urinary albumin in 24 h（TP/24 h） and renal function of patients in both groups. Results：The total effective rate was 72.5% in the treatment group and was 35.0% in the control group, the difference being significant（P〈0.05）. After treatment, the comparison of Chinese medicine syndrome scores between the two groups showed significance in differences（P〈0.05）. Compared TP/24 h,UAER,creatinine（Cr） and CRP in the treatment group before and after treatment,differences were significant（P〈0.05）. Compared TP/24 h,UAER,Cr and CRP between the two groups, differences showed significant（P〈0.05）. No significant difference was found in the comparison of HbA1 c of the two groups before and after treatment and the comparison of HbA1 c after treatment between the two groups（P〈0.05）. Conclusion：Yishen Yangyin Tongluo prescription can effectively reduce urine protein of patients with type 2 diabetes nephropathy of qi-yin deficiency type at stage Ⅲ and improve clinical symptom of patients.

关 键 词：2型糖尿病肾病Ⅲ期 气阴两虚型 中西医结合疗法 益肾养阴通络方 尿蛋白排泄率(UACR) 糖化血红蛋白(HbA1c) 24 h微量白蛋白(TP/24 h) C-反应蛋白(CRP) 

分 类 号：R587.2[医药卫生—内分泌]