柴芍六君子汤联合PegIFNα-2a治疗HBeAg阳性慢性乙型肝炎的临床观察  

Observation on chronic viral hepatitis B treated with Chaishao Liujunzi decoction combined with interferon alpha-2a

作　　者：吕建林[1] 毛德文[1] 张荣臻[1] 宁碧泉 柳琳琳[2] 

机构地区：[1]广西中医药大学第一附属医院,广西南宁530023 [2]广西中医药大学,广西南宁530001

出　　处：《中国中西医结合消化杂志》2018年第2期144-147,151,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家"十一五"科技重大专项项目(No:2008ZX10005-007);国家科技重大专项课题(No:2012ZX10005004-003);广西壮族自治区卫生和计划生育委员会自筹经费科研课题(No:Z2015472)

摘　　要：[目的]观察柴芍六君子汤联合聚乙二醇干扰素(PegIFNα-2a)治疗HBeAg阳性慢性乙型性肝炎的临床疗效。[方法]将90例符合纳入标准的患者按照随机数字表法分为试验组47例和对照组43例,对照组予PegIFNα-2a治疗,试验组在对照组基础上给加用柴芍六君子汤治疗,治疗24周为1个疗程。通过评价2组肝功能(ALT、AST)情况、HBeAg阴转率、HBV-DNA阴转率、HBeAg血清学转换率、临床症状改善、不良反应发生率等观察柴芍六君子汤联合PegIFNα-2a疗效。[结果]试验组在降低转氨酶、HBeAg阴转率、HBV-DNA阴转率、HBeAg血清学转换率、临床症状改善、不良反应发生率方面均优于对照组(P<0.05)。[结论]柴芍六君子汤可提高PegIFN-α2a治疗HBeAg阳性慢性乙型肝炎的抗病毒疗效,改善生活质量,减少PegIFNα-2a不良反应。[Objective]To observe the Chaishao Liujunzi decoction combined with PegIFNα-2 aon chronic viral hepatitis B.[Methods]90 cases were randomlydivided into experimental group（47 cases）and the control group（43 cases）.The control group were given PegIFNα-2 a,while the experimental group were treated by Chaishao Liujunzi decoction combined PegIFNα-2 a.The treatment lasted 24 weeks.Clinical efficacy was observed by assessing ALT,HBeAg negative conversion rate,HBV DNA negative conversion rate,HBeAg serological conversion rate,improvement of clinical symptoms,and adverse effects rate.[Results]Better effects were achieved in experimental group on reduced transaminase,HBeAg negative conversion rate,HBV DNA negative conversion rate,HBeAg serological conversion rate,and improvement of clinical symptoms.Adverse effects rate was lower than that of control group.[Conclusion]Chaishao Liujunzi decoction can improve the antiviral efficacy of PegIFNα-2 ain treating HBeAg positive chronic hepatitis B,improve quality of life,and reduce adverse reaction of PegIFNα-2 a.

关 键 词：慢性乙型肝炎 柴芍六君子汤 PegIFNα-2a 

分 类 号：R512.62[医药卫生—内科学]