阿魏属药用植物的物质基础  

Bioactive Material Basis of Medicinal Plants in Genus Ferula

作　　者：杨秀伟[1,2] 

机构地区：[1]北京大学天然药物及仿生药物国家重点实验室,北京100191 [2]北京大学药学院天然药物学系,北京100191

出　　处：《中国现代中药》2018年第2期123-144,共22页Modern Chinese Medicine

基　　金："十二五"国家科技支撑项目(2011BAI07B08)

摘　　要：阿魏属在植物分类学上归类为伞形科,全球约150余种,其中13个物种在我国药用。本文评述其化学成分和生物学活性以及临床应用。阿魏属药用植物中单萜、倍半萜和香豆素类化合物无论是在含量上还是在化学结构多样性上,占绝对优势地位,它们可能是阿魏属药用植物的重要生物活性物质基础之一。最具特色的是该属的大部分单萜或倍半萜类化合物在化学结构类型上杂合香豆素的结构单元。该属药用植物的许多活性诸如细胞毒、抗菌、抗病毒、P-糖蛋白抑制和抗炎等皆与单萜杂合香豆素或倍半萜杂合香豆素化合物有关。这些研究结果能够用于阿魏属药用植物的药用亲缘学研究。Genus Ferula is taxonomically classified as a member of Umbelliferae and a genus of well over 150 species in global,13 of which are medicinal in China. In this article,studies on their chemical constituents and biological activities as well as clinical uses were reviewed. The monoterpenoid,sesquiterpenoid and coumarin compounds are predominantly dominant type not only in amount but also in structural varieties,which should be one of important bioactive material basis of medicinal plants in the genus Ferula. The most characteristic feature of many monoterpenoid or sesquiterpenoid compounds in genus Ferula is embellished having the structural unit of coumarins. Many biological features of medicinal plants in this genus such as cytotoxicity,antibacterial,antiviral,P-glycoprotein inhibitory and antiinflammatory activities have been attributed to monoterpene-coumarin or sesquiterpene-coumarin. These results could be used for pharmaphylogenic research of the medicinal herbs in genus Ferula.

关 键 词：阿魏属 生物活性物质基础 单萜杂合香豆素 倍半萜杂合香豆素 

分 类 号：R284[医药卫生—中药学]