艾司西酞普兰治疗脑卒中后抑郁及对患者神经功能认知功能的影响  

The Effect of Escitalopram on the Neurologic Function and Cognitive Function of the Post-stroke Depression Patients

作　　者：胡会婷 王敏忠[1] 

机构地区：[1]山东大学附属省立医院神经内科,山东济南250021 [2]山东省菏泽市牡丹人民医院神经内科,山东菏泽274000

出　　处：《河北医学》2018年第2期325-328,共4页Hebei Medicine

基　　金：山东省卫生厅科研计划项目;(编号:2012ws1783)

摘　　要：目的:探究艾司西酞普兰对脑卒中后抑郁患者神经功能、认知功能的影响。方法:选取本院于2016年10月至2017年10月收治的82例脑卒中后抑郁患者为研究对象,采用随机数字表法将其随机分为研究组(41例)和对照组(41例),两组患者均进行常规药物治疗,研究组患者在常规药物治疗的基础上服用艾司西酞普兰,对照组患者在常规药物治疗的基础上服用安慰剂,连续治疗12周。比较两组患者治疗前后的抑郁情况、神经功能、认知功能及生活能力进行评定。结果:治疗前两组患者的HAMD评分、NIHSS评分、MMSE评分及FIM评分差异无统计学意义(P>0.05),治疗后两组患者的HAMD评分、NIHSS评分、MMSE评分及FIM评分均有所改善,且观察组明显优于对照组(P<0.05)。结论:在脑卒中后抑郁的临床治疗中采用艾司西酞普兰治疗能促进患者神经功能、认知功能的改善,同时也能改善患者抑郁情况以及生活能力。Objective： To explore the effect of Ai Sciplan on the neural function and cognitive function of patients with post-stroke depression. Methods： 82 stroke patients were selected in our hospital from October 2016 to October 2017 were patients with depression as the research object,it was divided into study group（41 cases） and control group（41 cases） by random number table method,two groups of patients were treated with routine drug treatment the study group,patients taking escitalopram on the basis of routine therapy,patients in control group received placebo on the basis of conventional drug treatment,continuous treatment for 12 weeks. The depression of two groups were compared before and after treatment,nerve function,the cognitive function and life ability The evaluation. Results： Before treatment,there was no significant difference in the HAMD score,NIHSS score,MMSE score and FIM score between the two groups（P 〉0.05）.After treatment,the HAMD scores,NIHSS scores,MMSE scores and FIM scores of the two groups were all improved,and the observation group was significantly better than the control group（P 〈 0.05）. Conclusion：In the clinical treatment of post-stroke depression,the use of escitalopram can improve neurological function and cognitive function,as well as improve depression and viability of patients.

关 键 词：艾司西酞普兰 脑卒中 抑郁 神经功能 认知功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]