围绝经期女性腹型肥胖与心血管疾病危险因素相关性研究  

Study on the correlation between abdominal obesity and risk factors of cardiovascular diseases among perimenopausal women

作　　者：许维娜[1] 郭君萍[1] 

机构地区：[1]杭州市五云山疗养院健康管理中心,浙江杭州310008

出　　处：《中国预防医学杂志》2018年第2期129-132,共4页Chinese Preventive Medicine

基　　金：杭州市卫生科技计划项目(2014A68;2014A69)

摘　　要：目的探讨围绝经期妇女腹型肥胖相关心血管疾病危险因素,为围绝经期妇女保健工作提供参考依据。方法选择2014年1月至2015年7月,杭州市五云山疗养院健康管理中心收集45~60岁围绝经期妇女健康体检资料数据,以分层整群概率比率法抽样调查,采用多因素线性回归分析其心血管危险相关因素。结果本研究共调查1 051人,腹型肥胖555例(52.81%)。腹型肥胖组的BMI(t=17.12,P<0.01),收缩压(SBP)(t=6.28,P<0.01);舒张压(DBP)(t=6.30,P<0.01);甘油三酯(TG)(t=3.69,P<0.01);低密度脂蛋白胆固醇(LDL-C)(t=3.38,P=0.001);空腹血糖(FPG)(t=3.26,P=0.001);血尿酸(UA)(t=5.77,P<0.01)及致动脉粥样硬化指数(AIP)(t=5.83,P<0.01)均高于非腹型肥胖组,差异有统计学意义,高密度脂蛋白胆固醇(HDL-C)水平低于非腹型肥胖组,差异有统计学意义(t=-5.78,P<0.01)。随着腰围升高,BMI(r=0.44,P<0.05);SBP(r=0.45,P<0.05);DBP(r=0.44,P<0.05);TG(r=0.11,P<0.05);FPG(r=0.08,P<0.05);UA(r=0.37,P<0.05);AIP(r=0.12,P<0.05)升高,HDL-C降低(r=-0.16,P<0.05)。多重线性回归分析的结果显示,SBP、BMI、UA、DBP升高,则腹型肥胖越严重。二分类logistic回归分析的结果显示,腹型肥胖与DBP(β=0.031);UA(β=0.004)呈正相关,而与HDL-C呈负相关(β=-1.189)。结论围绝经期妇女随着腰围增加,患心血管疾病的危险增大,应将合理控制腰围作为围绝经期妇女慢性病保健的优先指标。Objective The aim of this study was to explore the correlation between central obesity and risk factors of cardiovascular diseases among perimenopausal women. Methods A stratified cluster sampling method was used to randomly select perimenopausal women aged 45-60 years who did physical examination in Wuyunshan Convalescent Hospital from January 2014 to July 2015.The multivariate linear regression analysis was used to analyze the correlation of interacting variables. Results Data of total 1 051 perimenopausal women were analyzed.Among them,555（52.81%）were abdominal obesity.The level of body mass index（BMI）,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,triglyceride（TG）,fasting plasma glucose（FPG）,Uric acid（UA）and atherogenic index of plasma（AIP）were all significantly higher among subjects with abdominal obesity compared with those with no abdominal obesity（t=17.12,6.28,6.30,3.69,3.38,3.26,5.77,5.83,P〈0.01）,while the level of high-density lipoprotein-cholesterol（HDL-C）was lower（t=-5.78,P〈0.01）.Along with the increase of waist circumference（WC）,all the above variables went up,except for HDL-C which went down（P〈0.05）.Multivariate linear regression analysis showed that central obesity was positively correlated with DBP（β= 0.031） and UA（β= 0.004）, while negatively correlated with HDL-C（β=-1.189）. Conclusions The risk of cardiovascular disease increases with the increase of WC among perimenopausal women.Therefore,WC control is critical for preventing perimonipausal women from chronic diseases such as cardiovascular disease.

关 键 词：围绝经期 腹型肥胖 腰围 心血管疾病 危险因素 女性 相关性分析 

分 类 号：R589.2[医药卫生—内分泌] R54[医药卫生—内科学]