唑来膦酸注射液致结膜炎伴上睑下垂  

Zoledronic acid injection induced conjunctivitis with blepharoptosis

作　　者：曹畅 尤丽敏 杜江涛 甘荷霞 蔡佳伟 史涛 

机构地区：[1]厦门大学附属成功医院药剂科,361005 [2]厦门大学附属成功医院神经内科,361005 [3]厦门大学附属成功医院眼科,361005

出　　处：《药物不良反应杂志》2018年第1期71-73,共3页Adverse Drug Reactions Journal

摘　　要：1例67岁女性患者因严重骨质疏松给予唑来膦酸注射液5 mg（100 ml）静脉滴注1次。24 h后患者出现双眼结膜充血、视物模糊，右眼为著，伴右眼睑上抬困难，给予氧氟沙星滴眼液、聚乙二醇滴眼液交替滴眼，症状无明显好转。第3天请眼科医师会诊，诊断为结膜炎伴上睑下垂，第4天改用妥布霉素地塞米松滴眼液和七叶洋地黄双苷滴眼液滴眼治疗。8 d后眼部症状消失。考虑患者结膜炎伴上睑下垂为唑来膦酸注射液所致。A 67-year-old female patient with severe osteoporosis received an intravenous infusion of zoledronic acid injection 5 mg （100 ml）. Twenty-four hours later, the patient developed conjunctival congestion in bilateral eyes, blurred vision, and difficult lifting of the right eyelid. Ofloxacin eye drops and polyethylene glycol eye drops were given, but the above symptoms were not improved markedly. On the 3rd day of zoledronate acid injection, conjunctivitis with blepharoptosis was diagnosed by an ophthalmologist. On the 4rd day, tobramycin dexamethasone eye drops and esculin and digitalisglycosides eye drops were given. Eight days later, the patient′s eyes discomfort disappeared. It was considered that conjunctivitis with blepharoptosis was induced by zoledronic acid injection.

关 键 词：结膜炎 眼睑下垂 唑来膦酸 

分 类 号：R969[医药卫生—药理学]