不同性别青年肥胖高血压患者醛固酮水平的变化  

Gender differences in the aldosterone level of young obese patients with hypertension

作　　者：李丽君[1] 侯小玲[1] 耿晓雯[1] 陈韵岱[1] 

机构地区：[1]中国人民解放军总医院心内科,北京100853

出　　处：《中华高血压杂志》2018年第1期56-60,共5页Chinese Journal of Hypertension

摘　　要：目的观察不同性别青年肥胖高血压患者醛固酮水平的变化。方法住院青年高血压患者319例,男性217例,女性102例。按照亚洲太平洋地区肥胖诊断标准,体质量指数(BMI)≥28kg/m2者为肥胖。空腹状态抽血化验各项指标,并于住院期间行卧立位试验检测血管紧张素Ⅱ(AngⅡ)、醛固酮水平。结果女性肥胖高血压患者卧位醛固酮水平低于男性[(407.37±169.59)比(470.09±159.67)pmol/L,P<0.05]。在男性青年高血压患者中,肥胖组患者的卧位醛固酮水平升高[(470.09±159.67)比(416.21±126.05)pmol/L,P<0.05],而在女性青年高血压患者中,肥胖组和非肥胖组患者间卧位醛固酮水平差异无统计学意义[(407.37±169.59)比(402.37±126.37)pmol/L,P>0.05]。在男性青年高血压患者中,醛固酮水平和BMI、收缩压水平呈正相关(r=0.195、0.216,P<0.05)。结论肥胖的男性青年高血压患者醛固酮水平显著增加,而肥胖与女性青年高血压患者醛固酮水平无关。Objective To investigate gender differences in the aldosterone level of young obese patients with hypertension. Methods A total of 319 young inpatients with hypertension were enrolled in this study,and there were217 male and 102 female. Obesity was defined as body mass index（BMI）≥28 kg/m^2 according to the diagnostic criteria of obesity for the Asia-Pacific region. All the patients underwent fasting blood tests and the recumbent-upright test,and the levels of angiotensin and aldosterone were detected during the hospitalization. Results The level of supine aldosterone in the female obese patients with hypertension was significantly lower than that in the male obese patients with hypertension[（407.37±169.59）vs（470.09±159.67）pmol/L,P〈0.05]. In the male young patients with hypertension,the supine aldosterone level was significantly increased in the obese group [（470.09±159.67）vs（416.21±126.05）pmol/L,P〈0.05]. While in the female young patients with hypertension,there were no significant differences in supine aldosterone level between obese and non-obese group[（407.37±169.59）vs（402.37±126.37）pmol/L,P〉0.05]. In the male young patients with hypertension,the aldosterone level significantly positively correlated with BMI and systolic blood pressure（r=0.195,0.216,both P〈0.05）. Conclusion The aldosterone level was significantly increased in the male young obese patients with hypertension,while obesity was not related to the aldosterone level in the female young patients with hypertension.

关 键 词：高血压 肥胖 醛固酮 性别差异 

分 类 号：R544.1[医药卫生—心血管疾病]