颅脑损伤后血清IL-1βIL6的变化及临床意义  

Changes and clinical significance of serum IL1-beta,IL6 in patients with brain injury

作　　者：钟宝 万野 邹敏 熊小军 

机构地区：[1]荆门市第二人民医院神经外二科,湖北荆门448000

出　　处：《中国实用神经疾病杂志》2018年第2期184-187,共4页Chinese Journal of Practical Nervous Diseases

基　　金：湖北省自然科学基金项目;编号:2016cfb110

摘　　要：目的通过测定炎症因子IL-1β、IL-6在颅脑损伤患者血清中的含量变化,探讨IL-1、IL-6与颅脑损伤程度以及预后的关系。方法选取2012-01—2015-12荆门市第二人民医院收治的256例颅脑损伤患者为研究对象,根据其颅脑损伤严重程度分为轻度组98例,中度组93例及重度组65例,选取同期本院门诊体检正常者50例为对照组,分别在受伤后第1天、第3天、第5天、第7天、第10天、第14天采用酶联免疫吸附法(ELISA)检测所有患者血清中的IL-1β、IL-6含量,对比不同组别之间IL-1β、IL-6的差异并分析其变化的临床意义;根据死亡、植物人、重残、中残、良好5种不同预后情况进行重新归纳分组,分析每组患者IL-1β、IL-6含量的差异并进行分析。结果颅脑损伤组患者血清中IL-1β、IL-6的含量均高于对照组(P<0.05),且重度颅脑损伤组血清IL-1β、IL-6含量明显高于轻度组和中度组(P<0.05),预后死亡组、植物生存状态组以及重残生存组的IL-1β、IL-6含量明显高于中残组和预后良好组(P<0.05),死亡组和植物生存组IL-1β、IL-6含量高于重残组,差异具有统计学意义(P<0.05)。结论炎症细胞因子IL-1β、IL-6在颅脑损伤患者血清中的含量与损伤严重程度以及预后有密切联系,检测其含量可以作为评估颅脑损伤程度的重要指标。Objective To investigate the relationship between 1L-1, 1L-6 and the degree of brain injury and prognosis of pa tients with brain injury. Methods 256 cases of craniocerebral injury patients admitted to our hospital from January 2012 to December 2015 were selected as the research objects, and divided into mild group （98 cases）, moderate group （ 93 cases） and severe group （65 cases） according to the severity of traumatic brain injury. Another 50 healthy cases received physical examination in our hospital were selected as the control group. The serum levels of IL-1 beta and IL-6 of all groups were assessed by using enzymelinked imnmnosorbent assay （ELISA） at one day, third days, fifth days, seventh days, tenth days and fourteenth days. Patients were assigned to death, severe disability,vegetative and residual groups based on the outcome,and the IL-1 beta and IL-6 content were compared. Results The serum IL-1 beta and IL-6 content in the craniocerebral injury group were higher than that of control group （P〈0.05）;the serum levels of IL-1 beta and IL-6 in the severe brain injury group were significantly higher than that in the mild group and moderate group （P〈0.05）. Death groups, vegetative state patients and patients with severe disability survival group had significant higher beta IIL-1, IL-6 content than that of other two groups （P〈0.05）. Death patient group and plant survival group had significant higher IL-1 beta and IL-6 content than that of patients with severe disability group （P〈0.05）. Conclusion The content of inflammatory cytokine IL-1 beta and IL-6 in the serum of patients with brain injury is closely related to the severity of injury and prognosis, and it can be an important index to evaluate the degree of brain injury.

关 键 词：颅脑损伤 白细胞介素-1Β 白介素-6 血清 预后 炎症反应 

分 类 号：R651.15[医药卫生—外科学]